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YES1 protein, human

Known as: YES1 Protein Tyrosine Kinase, Proto-Oncogene c-Yes, Tyrosine-Protein Kinase Yes 
Tyrosine-protein kinase Yes (543 aa, ~61 kDa) is encoded by the human YES1 gene. This protein plays a role in both receptor tyrosine kinase-mediated… 
National Institutes of Health

Related topics

Related topics

17 relations
Cell Differentiation processCell ProliferationEnzyme GeneGenes, src

Broader (2)

Protein Tyrosine KinaseProto-Oncogene Proteins c-yes

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2020
2020
MiR-133 Targets YES1 and Inhibits the Growth of Triple-Negative Breast Cancer Cells
Triple-negative breast cancer shows worse outcome compared with other subtypes of breast cancer. The discovery of dysregulated… 
2020
2020
Overexpression of YES1 is associated with favorable prognosis and increased platinum-sensitivity in patients with epithelial ovarian cancer.
AIMS The prognostic application of YES1 in epithelial ovarian cancer (EOC) is currently unclear. We aimed to investigate the… 
2020
2020
Role of YES1 amplification in EGFR mutation‐positive non‐small cell lung cancer: Primary resistance to afatinib in a patient
Epidermal growth factor receptor (EGFR) mutation‐positive non‐small cell lung cancer (NSCLC) patients benefit from EGFR tyrosine… 
2018
2018
Abstract 4126: DNA methyltransferase inhibitors target a YES1-YAP1 signaling axis in childhood rhabdomyosarcoma
We have previously shown that the SRC family kinase (SFK) member, YES1, is highly expressed and rapidly activated upon IGF-1R… 
2017
2017
Yes1 signaling mediates the resistance to Trastuzumab/Lap atinib in breast cancer
Background Overexpression of human epidermal growth factor receptor 2 (HER2) is observed in approximately 15–23% of breast… 
2016
2016
Abstract 4392: Yes1 is the key molecule for the resistance to trastuzumab in breast cancer, and dasatinib overcomes the resistance
Background: Overexpression of human epidermal growth factor receptor 2 (HER2) was observed in approximately 15-23% of breast… 
2014
2014
Inhibitory effect of miR-205 targeted YES1 on proliferation of A549 cells
Objective To detect the expression levels of the miR-205in lung cancer tissue and A549cells and its targeted gene YES1using qRT… 
2013
2013
Running title: Role of YES1 in testicular heat stress Summary sentence: Activation of YES1 tyrosine kinase in pachytene spermatocytes is required for maintaining apoptotic balance in response to…
Deregulated expression of protein tyrosine phosphorylation has been implicated in testicular response to different stimuli… 
Highly Cited
2012
Highly Cited
2012
Opening Pandora's jar: a primer on the putative roles of CRMP2 in a panoply of neurodegenerative, sensory and motor neuron, and central disorders.
CRMP2, also known as DPYSL2/DRP2, Unc-33, Ulip or TUC2, is a cytosolic phosphoprotein that mediates axon/dendrite specification… 
2002
2002
QM, a Putative Tumor Suppressor, Regulates Proto-oncogene c-Yes*
The QM gene encodes a 24.5 kDa ribosomal protein L10 known to be highly homologous to a Jun-binding protein (Jif-1), which… 
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