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The human gut contains trillions of microorganisms that influence our health by metabolizing xenobiotics, including host-targeted… Expand Xenobiotic resistance in insects has evolved predominantly by increasing the metabolic capability of detoxificative systems and… Expand Irrespective of the morphological features of end-stage cell death (that may be apoptotic, necrotic, autophagic, or mitotic… Expand Flavonoids are present in fruits, vegetables and beverages derived from plants (tea, red wine), and in many dietary supplements… Expand Multidrug Resistance Proteins (MRPs), together with the cystic fibrosis conductance regulator (CFTR/ABCC7) and the sulfonylurea… Expand Drug metabolizing enzymes (DMEs) play central roles in the metabolism, elimination and detoxification of xenobiotics and drugs… Expand Abstract. Cytochromes P450 (henceforth P450s) are involved in a variety of metabolic and biosynthetic processes. The number of… Expand The induction of phase II detoxifying enzymes is an important defense mechanism against intake of xenobiotics. While this group… Expand The role of reactive oxygen species, with the subsequent oxidative deterioration of biological macromolecules in the toxicities… Expand A free radical is any molecule that has an odd number of electrons. Free radicals, which can occur in both organic (i.e… Expand