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Wegener Autoantigen

Known as: Myeloblastin, C-ANCA Antigen, Proteinase 3 
Myeloblastin (256 aa, ~28 kDa) is encoded by the human PRTN3 gene. This protein is involved in the proteolysis of extracellular matrix proteins.
National Institutes of Health

Related topics

Related topics

13 relations
Enzyme GeneExtracellular SpaceGranulomatosis with polyangiitisHomo sapiens

Broader (1)

Myeloblastin

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2011
Review
2011
The influence of early life factors on the risk of developing rheumatoid arthritis
Rheumatoid arthritis (RA) is a chronic inflammatory disease that develops as a result of the interaction between genetic and… 
Review
2010
Review
2010
Antibodies to citrullinated proteins: molecular interactions and arthritogenicity
Summary:  The discovery of antibodies specific for citrullinated protein epitopes [anti‐citrullinated protein antibodies (ACPAs… 
Highly Cited
2003
Highly Cited
2003
Imposex and organotin concentrations in Buccinum undatum and Neptunea antiqua from the North Sea: relationship to shipping density and hydrographical conditions.
Highly Cited
1999
Highly Cited
1999
Mapping of a Hypovirus p29 Protease Symptom Determinant Domain with Sequence Similarity to Potyvirus HC-Pro Protease
ABSTRACT Hypovirus infection of the chestnut blight fungusCryphonectria parasitica results in a spectrum of phenotypic changes… 
Highly Cited
1998
Highly Cited
1998
Capture-ELISA based on recombinant PR3 is sensitive for PR3-ANCA testing and allows detection of PR3 and PR3-ANCA/PR3 immunecomplexes.
Highly Cited
1996
Highly Cited
1996
Radioimmunotherapy of patients with small-volume tumors using iodine-131-labeled anti-CEA monoclonal antibody NP-4 F(ab')2.
UNLABELLED The clinical feasibility of radioimmunotherapy (RIAIT) was assessed in patients with metastatic, carcinoembryonic… 
Highly Cited
1995
Highly Cited
1995
Characterization of monoclonal antibodies to proteinase-3 and application in the study of epitopes for classical anti-neutrophil cytoplasm antibodies.
Wegener's granulomatosis is associated with autoantibodies (classical antineutrophil cytoplasm antibodies, c-ANCAs) to a serine… 
Highly Cited
1991
Highly Cited
1991
Proteinase 3, the target antigen of anticytoplasmic antibodies circulating in Wegener's granulomatosis. Immunolocalization in normal and pathologic tissues.
Proteinase 3 was identified as the target antigen of anticytoplasmic antibodies (ACPA/c-ANCA) in Wegener's granulomatosis (WG… 
Highly Cited
1990
Highly Cited
1990
The new ACPA/ANCA nomenclature.
Highly Cited
1977
Highly Cited
1977
"gag" polyprotein precursors of Rauscher murine leukemia virus.
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