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WYE 125132

Known as: WYE-125132, WYE125132 
 
National Institutes of Health

Related topics

Related topics

3 relations

Broader (2)

Phenylurea CompoundsPyrazoles

Narrower (1)

WYE-132

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2012
2012
Biochemical and pharmacological inhibition of mTOR by rapamycin and an ATP-competitive mTOR inhibitor.
The mammalian target of rapamycin (mTOR) is the catalytic subunit of two multiprotein complexes, mTOR complex-1 (mTORC1) and mTOR… Expand
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Highly Cited
2010
Highly Cited
2010
Beyond rapalog therapy: preclinical pharmacology and antitumor activity of WYE-125132, an ATP-competitive and specific inhibitor of mTORC1 and mTORC2.
The mammalian target of rapamycin (mTOR) is a major component of the phosphoinositide 3-kinase (PI3K)/AKT signaling pathway that… Expand
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Highly Cited
2010
Highly Cited
2010
Requirement of the mTOR Kinase for the Regulation of Maf1 Phosphorylation and Control of RNA Polymerase III-dependent Transcription in Cancer Cells
The mammalian target of rapamycin (mTOR) regulates growth via promoting translation and transcription. Here, employing an mTOR… Expand
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