FAQ

WRAP53 wt Allele

Known as: TCAB1, DKCB3, WDR79 
Human WRAP53 wild-type allele is located in the vicinity of 17p13.1 and is approximately 17 kb in length. This allele, which encodes telomerase Cajal… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1999-2017
02419992017

Related topics

Related topics

4 relations
17p13.1RNA BindingTelomere Maintenance

Broader (1)

WRAP53 gene

Related mentions per year

Related mentions per year

1968-2018
1960198020002020
WRAP53 wt Allele
RNA Binding
Telomere Maintenance
17p13.1
WRAP53 gene

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2016
2016
Minimized human telomerase maintains telomeres and resolves endogenous roles of H/ACA proteins, TCAB1, and Cajal bodies
We dissected the importance of human telomerase biogenesis and trafficking pathways for telomere maintenance. Biological… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
2014
2014
Targeting vertebrate intron-encoded box C/D 2′-O-methylation guide RNAs into the Cajal body
Post-transcriptional pseudouridylation and 2'-O-methylation of splicesomal small nuclear ribonucleic acids (snRNAs) is mediated… (More)
Is this relevant?
2014
2014
TCAB1: a potential target for diagnosis and therapy of head and neck carcinomas
WRAP53, including α, β and γ isoforms, plays an important role not only in the stability of p53 mRNA, but also in the assembly… (More)
  • table 1
  • figure 1
  • figure 2
  • figure 3
  • figure 4
Is this relevant?
2012
2012
Telomerase recruitment requires both TCAB1 and Cajal bodies independently.
The ability of most cancer cells to grow indefinitely relies on the enzyme telomerase and its recruitment to telomeres. In human… (More)
Is this relevant?
2011
2011
An inducible nuclear body in the Drosophila germinal vesicle.
When living egg chambers of Drosophila are isolated in a saline solution and gently squashed between a microscope slide and… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
2011
Highly Cited
2011
Disruption of telomerase trafficking by TCAB1 mutation causes dyskeratosis congenita.
Dyskeratosis congenita (DC) is a genetic disorder of defective tissue maintenance and cancer predisposition caused by short… (More)
Is this relevant?
Highly Cited
2009
Highly Cited
2009
A conserved WD40 protein binds the Cajal body localization signal of scaRNP particles.
Small Cajal body (CB)-specific RNPs (scaRNPs) function in posttranscriptional modification of small nuclear (sn)RNAs. An RNA… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
2009
2009
Large-scale evaluation of candidate genes identifies associations between DNA repair and genomic maintenance and development of benzene hematotoxicity.
Benzene is an established human hematotoxicant and leukemogen but its mechanism of action is unclear. To investigate the role of… (More)
  • figure 1
  • figure 2
  • table I
  • table II
  • table III
Is this relevant?
2009
2009
TCAB1: driving telomerase to Cajal bodies.
Telomerase supports the proliferation of progenitor cells and tumor cells by adding telomere repeats to chromosome ends. The low… (More)
Is this relevant?
2007
2007
Common genetic variation in TP53 and its flanking genes, WDR79 and ATP1B2, and susceptibility to breast cancer.
Germline mutations in the tumor suppressor gene TP53 are associated with high incidence of early-onset malignancies, and somatic… (More)
  • figure 1
  • table I
  • table II
  • table III
  • table IV
Is this relevant?