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WRAP53 wt Allele
Known as:
TCAB1
, DKCB3
, WDR79
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Human WRAP53 wild-type allele is located in the vicinity of 17p13.1 and is approximately 17 kb in length. This allele, which encodes telomerase Cajal…
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National Institutes of Health
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Related topics
Related topics
4 relations
17p13.1
RNA Binding
Telomere Maintenance
Broader (1)
WRAP53 gene
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
WDR79 promotes the proliferation of non-small cell lung cancer cells via USP7-mediated regulation of the Mdm2-p53 pathway
Yang Sun
,
L. Cao
,
+9 authors
Mao Ye
Cell death & disease
2017
Corpus ID: 4732841
WD repeat protein 79 (WDR79) is a member of the WD-repeat protein family and functions as a scaffold protein during telomerase…
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2016
2016
Minimized human telomerase maintains telomeres and resolves endogenous roles of H/ACA proteins, TCAB1, and Cajal bodies
Jacob M. Vogan
,
Xiaozhu Zhang
,
+4 authors
K. Collins
eLife
2016
Corpus ID: 18053804
We dissected the importance of human telomerase biogenesis and trafficking pathways for telomere maintenance. Biological…
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2013
2013
Catalytically active telomerase holoenzyme is assembled in the dense fibrillar component of the nucleolus during S phase
Ji Hoon Lee
,
Yangsin Lee
,
Sun Ah Jeong
,
Prabhat Khadka
,
J. Roth
,
I. Chung
Histochemistry and Cell Biology
2013
Corpus ID: 7020920
The maintenance of human telomeres requires the ribonucleoprotein enzyme telomerase, which is composed of telomerase reverse…
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Highly Cited
2012
Highly Cited
2012
Telomerase Recruitment Requires both TCAB1 and Cajal Bodies Independently
J. Stern
,
Katherine G. Zyner
,
H. Pickett
,
Scott B. Cohen
,
T. Bryan
Molecular and Cellular Biology
2012
Corpus ID: 24645704
ABSTRACT The ability of most cancer cells to grow indefinitely relies on the enzyme telomerase and its recruitment to telomeres…
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2012
2012
The relationship between DNA methylation and telomere length in dyskeratosis congenita
S. Gadalla
,
H. Katki
,
F. Shebl
,
N. Giri
,
B. Alter
,
S. Savage
Aging cell
2012
Corpus ID: 19214552
The regulation of telomere length (TL) is a complex process, requiring the telomerase enzyme complex and numerous regulatory…
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Highly Cited
2011
Highly Cited
2011
Telomere shortening and loss of self-renewal in dyskeratosis congenita iPS cells
L. F. Batista
,
Matthew F. Pech
,
+14 authors
S. Artandi
Nature
2011
Corpus ID: 4343613
The differentiation of patient-derived induced pluripotent stem cells (iPSCs) to committed fates such as neurons, muscle and…
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Highly Cited
2011
Highly Cited
2011
Disruption of telomerase trafficking by TCAB1 mutation causes dyskeratosis congenita.
F. Zhong
,
S. Savage
,
+6 authors
S. Artandi
Genes & development
2011
Corpus ID: 23753639
Dyskeratosis congenita (DC) is a genetic disorder of defective tissue maintenance and cancer predisposition caused by short…
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Review
2011
Review
2011
Dyskeratosis congenita.
I. Dokal
Hematology. American Society of Hematology…
2011
Corpus ID: 24634244
Dyskeratosis congenita (DC) is a multisystem inherited syndrome exhibiting marked clinical and genetic heterogeneity. In its…
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Highly Cited
2009
Highly Cited
2009
TCAB1: Driving telomerase to Cajal bodies
A. Venteicher
,
S. Artandi
Cell cycle
2009
Corpus ID: 27921068
Telomerase supports the proliferation of progenitor cells and tumor cells by adding telomere repeats to chromosome ends. The low…
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Highly Cited
2007
Highly Cited
2007
Common genetic variation in TP53 and its flanking genes, WDR79 and ATP1B2, and susceptibility to breast cancer
M. García-Closas
,
V. Kristensen
,
+12 authors
S. Chanock
International journal of cancer
2007
Corpus ID: 25769110
Germline mutations in the tumor suppressor gene TP53 are associated with high incidence of early‐onset malignancies, and somatic…
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