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WR 151327

Known as: 1-Propanethiol, 3-((3-(methylamino)propyl)amino)-, dihydrogen phosphate (ester), WR-151327 
National Institutes of Health

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Organothiophosphorus Compounds

Papers overview

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Highly Cited
2010
Highly Cited
2010
COMBINED INJURY: FACTORS WITH POTENTIAL TO IMPACT RADIATION DOSE ASSESSMENTS
Combined injuries, which are expected after a radiation dispersal device release or nuclear weapon detonation, are the… 
2001
2001
Radioprotective and locomotor responses of mice treated with nimodipine alone and in combination with WR‐151327
The effect of combining a radiation‐protective phosphorothioate with another agent was investigated in an attempt to increase… 
2000
2000
WR-151327 increases resistance to Klebsiella pneumoniae infection in mixed-field- and gamma-photon-irradiated mice.
PURPOSE To determine the efficacy of WR-151327 (WR) [S-3-(3-methylaminopropylamino) propylphosphorothioic acid; (CH3-HN-(CH2)3-NH… 
1994
1994
Preclinical evaluation of WR-151327: an orally active chemotherapy protector.
Clinical trials are in progress to evaluate radio- and chemoprotection by the aminothiol 2-[(3-aminopropyl)amino]ethanethiol… 
1994
1994
Organic thiophosphate WR-151327 suppresses expression of HIV in chronically infected cells.
Reducing agents such as glutathione (GSH), glutathione ester (GSE), and N-acetylcysteine (NAC) have been shown to suppress the… 
1994
1994
Survival of irradiated mice treated with WR-151327, synthetic trehalose dicorynomycolate, or ofloxacin.
1992
1992
Pathological evaluation of WR-151327 administered orally in irradiated and non-irradiated male mice.
Studies were made on the radioprotective and toxic effects of orally administered WR-151327 in male CD2F1 mice. The lowest dose… 
1991
1991
Protection by WR-151327 against late-effect damage from fission-spectrum neutrons.
The mutagenic and carcinogenic properties of fission-spectrum neutrons (KERMA-weighted mean energy of 0.85 MeV) from Argonne… 
1990
1990
Pathological effects of the radiation protector WR-151327 in mice.
The systemic effects of the radiation protective agent, S-3-(3-methylaminopropylamino) propylphosphorothioic acid (WR-151327… 
1987
1987
Protection of mice against fission neutron irradiation by WR-2721 or WR-151327.
Two phosphorothioate compounds, WR-2721 and WR-151327, were examined for their radioprotective efficacies against the effects of… 
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