C. Sigdestad

Publications71
h-index21
Citations1,201
Highly Influential Citations13
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Diurnal fluctuations in the number of cells in mitosis and DNA synthesis in the jejunum of the mouse.
Abstract At three hour intervals throughout the day mice were injected with 3HTdR and sacrificed 30 min later. Crypts were dissected for radioassay and radioautography and d.p.m./crypt,… Expand
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A comparison of radioprotection from three neutron sources and 60Co by WR-2721 and WR-151327.
Two thiophosphoroate radiation protectors (WR-2721 and WR-151327) were assessed for their ability to modify the effects of neutron or gamma irradiation on the gastrointestinal tract. Three neutron… Expand
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Radiation protectors: the unexpected benefits.
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A quantitative description of the intestinal epithelium of the mouse.
The use of combined cell kinetic, tritiated thymidine labeling and liquid scintillation counting techniques has permitted quantification of several intestinal epithelial cell parameters. Wet weight… Expand
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Intestinal crypt survival: the effect of cobalt-60, 250-kVcp x-rays and fission neutrons.
Intestinal crypt survival was studied using the method of Hagemann, Sigdestad and Lesher (8) in mice irradiated with 250 kVcp x-rays, cobalt-60 and fission neutrons. The D0's for the three treatmen...
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Gastrointestinal Radiation Injury
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The effect of 2-[(aminopropyl)amino] ethanethiol (WR-1065) on radiation induced DNA double strand damage and repair in V79 cells.
Radiation induced DNA double strand breaks are believed to be important lesions involved in processes related to cell killing, induction of chromosome aberrations and carcinogenesis. This paper… Expand
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Effect of chemical protectors on the response of the intestine to roentgen or fission neutron irradiation.
The monosodium salt S-1-(2-hydroxy-3-amino) propylphosphorothioic acid (WR-77913) and S-2-amino ethylisothiuronium-Br-HBr (AET) were tested for protective effects against 4 MeV roentgen irradiation… Expand
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Modification of radiation response in mice by fractionated extracts of Panax ginseng.
A water-soluble extract of the root of Panax ginseng, a plant native to northeastern China, was fractionated into three components: carbohydrate, protein, and saponin fractions. The fractions… Expand
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Protection against radiation-induced mutagenesis in V79 cells by 2-[(aminopropyl)amino] ethanethiol under conditions of acute hypoxia.
The effects of the radioprotector 2-[(aminopropyl)amino] ethanethiol (WR-1065) on radiation-induced cell killing and mutagenesis at the hypoxanthine-guanine phosphoribosyl transferase (HGPRT) locus… Expand
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