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Diurnal fluctuations in the number of cells in mitosis and DNA synthesis in the jejunum of the mouse.
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A comparison of radioprotection from three neutron sources and 60Co by WR-2721 and WR-151327.
TLDR
Two thiophosphoroate radiation protectors were assessed for their ability to modify the effects of neutron or gamma irradiation on the gastrointestinal tract and results did not correlate with the intestinal stem cell assays where WR-2721 when compared to WR-151327 showed either similar (DOSAR; fission spectrum neutrons) or somewhat better (60Co and FERMILAB neutrons).
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Radiation protectors: the unexpected benefits.
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A quantitative description of the intestinal epithelium of the mouse.
The use of combined cell kinetic, tritiated thymidine labeling and liquid scintillation counting techniques has permitted quantification of several intestinal epithelial cell parameters. Wet weight…
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Intestinal crypt survival: the effect of cobalt-60, 250-kVcp x-rays and fission neutrons.
Intestinal crypt survival was studied using the method of Hagemann, Sigdestad and Lesher (8) in mice irradiated with 250 kVcp x-rays, cobalt-60 and fission neutrons. The D0's for the three treatmen...
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The effect of 2-[(aminopropyl)amino] ethanethiol (WR-1065) on radiation induced DNA double strand damage and repair in V79 cells.
TLDR
The results indicate that WR-1065 is an effective protector against the formation of radiation-induced double-strand breaks in DNA as measured using a neutral elution technique at either pH 7.2 or pH 9.6.
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Cytotoxic effect in vivo of selected chemotherapeutic agents on synchronized murine fibrosarcoma cells.
The cytotoxic effects in vivo of single doses of either adriamycin (ADM), 1-beta-D-arabinofuranosylcytosine (Ara-C), bleomycin (BLM), cis-diamminedichloroplatinum (II) (cis-DDP), or cyclophosphamide…
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Effect of chemical protectors on the response of the intestine to roentgen or fission neutron irradiation.
TLDR
The monosodium salt S-1-(2-hydroxy-3-amino) propylphosphorothioic acid and AET were tested for protective effects against 4 MeV roentgen irradiation and fission neutrons in the mouse intestine and showed both compounds to be good protectors in animals.
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Modification of radiation response in mice by fractionated extracts of Panax ginseng.
TLDR
The results indicated that the water soluble extract of whole ginseng gave the best protection against gamma radiation, while the saponin fraction did not protect.
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Protection against radiation-induced mutagenesis in V79 cells by 2-[(aminopropyl)amino] ethanethiol under conditions of acute hypoxia.
TLDR
The results suggest that the antimutagenic effect of WR-1065 is not due solely to its ability to scavenge radiation-induced oxygen-free radicals, but rather that it may also modulate these effects through the scavenging of metabolically induced free radicals and/or the chemical repair of radiation- induced DNA lesions.
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