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WFS1 gene
Known as:
WOLFRAMIN
, WFS1
, WFS
Â
(More)
Â
National Institutes of Health
Topic mentions per year
Topic mentions per year
1979-2018
0
5
10
1979
2018
Related topics
Related topics
2 relations
Rats, Inbred WF
Wolfram Syndrome
Related mentions per year
Related mentions per year
1965-2018
1960
1980
2000
2020
WFS1 gene
Wolfram Syndrome
Rats, Inbred WF
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2010
Highly Cited
2010
Wolfram syndrome 1 gene negatively regulates ER stress signaling in rodent and human cells.
Sonya G. Fonseca
,
Shinsuke Ishigaki
,
+8 authors
Fumihiko Urano
The Journal of clinical investigation
2010
Wolfram syndrome is an autosomal-recessive disorder characterized by insulin-dependent diabetes mellitus, caused by nonautoimmune…Â
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2009
2009
Valproate, a Mood Stabilizer, Induces WFS1 Expression and Modulates Its Interaction with ER Stress Protein GRP94
Chihiro Kakiuchi
,
Shinsuke Ishigaki
,
Christine M. Oslowski
,
Sonya G. Fonseca
,
T. Ishioka R. Yamaoka H. Schmeer P. Starkey Kato
,
Fumihiko Urano
PloS one
2009
BACKGROUND Valproate is a standard treatment for bipolar disorder and a first-line mood stabilizer. The molecular mechanisms…Â
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2008
2008
Impact of polymorphisms in WFS1 on prediabetic phenotypes in a population-based sample of middle-aged people with normal and abnormal glucose regulation
Thomas Hempel Sparsø
,
Guro Lillemoen Andersen
,
+10 authors
T. Hansen
Diabetologia
2008
Recently, variants in WFS1 have been shown to be associated with type 2 diabetes. We aimed to examine metabolic risk phenotypes…Â
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Highly Cited
2006
Highly Cited
2006
WFS1-deficiency increases endoplasmic reticulum stress, impairs cell cycle progression and triggers the apoptotic pathway specifically in pancreatic beta-cells.
Takahiro Yamada
,
Hisamitsu Ishihara
,
+10 authors
Yoshitomo Oka
Human molecular genetics
2006
Wolfram syndrome, an autosomal recessive disorder associated with diabetes mellitus and optic atrophy, is caused by mutations in…Â
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2006
2006
WFS1 protein modulates the free Ca(2+) concentration in the endoplasmic reticulum.
Daisuke Takei
,
Hisamitsu Ishihara
,
+5 authors
Yoshitomo Oka
FEBS letters
2006
The WFS1 gene, encoding an endoplasmic reticulum (ER) membrane glycoprotein, is mutated in Wolfram syndrome characterized by…Â
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2006
2006
XBP1 induces WFS1 through an endoplasmic reticulum stress response element-like motif in SH-SY5Y cells.
Chihiro Kakiuchi
,
Mizuho Ishiwata
,
Akiko Hayashi
,
T. Ishioka R. Yamaoka H. Schmeer P. Starkey Kato
Journal of neurochemistry
2006
XBP1 is a key transcription factor in the endoplasmic reticulum (ER) stress response pathway. In a previous study, we suggested a…Â
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Highly Cited
2005
Highly Cited
2005
WFS1 is a novel component of the unfolded protein response and maintains homeostasis of the endoplasmic reticulum in pancreatic beta-cells.
Sonya G. Fonseca
,
M. Fukuma
,
+4 authors
Fumihiko Urano
The Journal of biological chemistry
2005
In Wolfram syndrome, a rare form of juvenile diabetes, pancreatic beta-cell death is not accompanied by an autoimmune response…Â
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2005
2005
Endoplasmic reticulum stress induces Wfs1 gene expression in pancreatic beta-cells via transcriptional activation.
Kohei Ueda
,
June Kawano
,
+10 authors
Yukio Tanizawa
European journal of endocrinology
2005
OBJECTIVE The WFS1 gene encodes an endoplasmic reticulum (ER) membrane-embedded protein. Homozygous WFS1 gene mutations cause…Â
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2004
2004
Genetic variations in the WFS1 gene in Japanese with type 2 diabetes and bipolar disorder.
Takanori Kawamoto
,
Yukio Horikawa
,
Takeshi Tanaka
,
Noriko Kabe
,
Jun Takeda
,
Masahiko Mikuni
Molecular genetics and metabolism
2004
Diabetic and psychiatric symptoms often appear in patients with Wolfram syndrome, and obligate carriers of WFS1 have increased…Â
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2004
2004
Endoplasmic reticulum stress and N-glycosylation modulate expression of WFS1 protein.
Suguru Yamaguchi
,
Hisamitsu Ishihara
,
+5 authors
Yoshitomo Oka
Biochemical and biophysical research…
2004
Mutations of the WFS1 gene are responsible for two hereditary diseases, Wolfram syndrome and low frequency sensorineural hearing…Â
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