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WFDC2 protein, human

Known as: WAP Domain Containing Protein HE4-V4, WAP four-disulfide core domain 2 protein, human, WFDC2 
WAP four-disulfide core domain protein 2 (124 aa, ~13 kDa) is encoded by the human WFDC2 gene. This protein may play a role in both proteinase… 
National Institutes of Health

Related topics

Related topics

7 relations
EpididymisExtracellular SpaceGenes, RegulatorMalignant neoplasm of ovary

Broader (1)

Proteins

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
WFDC2 contributes to epithelial–mesenchymal transition (EMT) by activating AKT signaling pathway and regulating MMP-2 expression
Objective: To understand the role of WFDC2 in metastasis of ovarian cancer. Methods: By knockdown or overexpression of WFDC2, we… 
2016
2016
Role of Zinc Supplementation in Testicular and Epididymal Damages in Diabetic Rat: Involvement of Nrf2, SOD1, and GPX5
Zinc (Zn) is one of the most important trace elements required for several biological processes. Diabetes negatively affects many… 
2015
2015
Selective inhibition of prostaglandin E2 receptors EP2 and EP4 modulates DNA methylation and histone modification machinery proteins in human endometriotic cells
Highly Cited
2014
Highly Cited
2014
HE4 (WFDC2) gene overexpression promotes ovarian tumor growth
Selective overexpression of Human epididymal secretory protein E4 (HE4) points to a role in ovarian cancer tumorigenesis but… 
Highly Cited
2013
Highly Cited
2013
HE4 (WFDC2) Promotes Tumor Growth in Endometrial Cancer Cell Lines
HE4, also known as WFDC2, is a useful biomarker for ovarian cancer when either used alone or in combination with CA125. HE4 is… 
Review
2013
Review
2013
Microvesicles as Potential Ovarian Cancer Biomarkers
Although the incidence of ovarian cancer is low (i.e., less than 5% in European countries), it is the most lethal gynecologic… 
Highly Cited
2012
Highly Cited
2012
Inhibition of EP4 Signaling Attenuates Aortic Aneurysm Formation
Background Aortic aneurysm is a common but life-threatening disease among the elderly, for which no effective medical therapy is… 
2012
2012
Serum HE4 concentration is not dependent on menstrual cycle or hormonal treatment among endometriosis patients and healthy premenopausal women.
Highly Cited
2011
Highly Cited
2011
Signaling via the prostaglandin E₂ receptor EP4 exerts neuronal and vascular protection in a mouse model of cerebral ischemia.
Stroke is the third leading cause of death in the United States. Fewer than 5% of patients benefit from the only intervention… 
2010
2010
Evaluation of erythrocyte band 3 phosphotyrosine level, glutathione content, CA-125, and human epididymal secretory protein E4 as combined parameters in endometriosis.
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