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WDR5 gene

Known as: WD REPEAT-CONTAINING PROTEIN 5, WD repeat domain 5, cilia and flagella associated protein 89 
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
The identification of novel small-molecule inhibitors targeting WDR5-MLL1 interaction through fluorescence polarization based high-throughput screening.
2018
2018
Sca1+Lin-CD117- Mouse Bone Marrow-Derived Mesenchymal Stem Cells Regulate Immature Dendritic Cell Maturation by Inhibiting TLR4-IRF8 Signaling Via the Notch-RBP-J Pathway.
Mesenchymal stem cells (MSCs) have a superior immunomodulatory capacity compared to other cells of the immune system, and they… 
2017
2017
Characterizing effects of small molecule inhibition of WDR5 in colorectal cancer
WDR5 is a core subunit of the MLL-WRAD methyltransferases, NSL-MOF acetyltransferases and MYC-MAX transcription factors… 
2016
2016
The MLL/Setd1b methyltransferase is required for the Spemann's organizer gene activation in Xenopus
2016
2016
LincRNA1230 inhibits the differentiation of mouse ES cells towards neural progenitors
In vitro, mouse embryonic stem (ES) cells can differentiate into many somatic cell types, including neurons and glial cells. When… 
2016
2016
Towards the construction of an interactome for Human WD40 protein family
WD40 proteins are involved in a variety of protein-protein interactions as part of a multi-protein assembly modulating diverse… 
2014
2014
Detection of insulin granule exocytosis by an electrophysiology method with high temporal resolution reveals enlarged insulin granule pool in BIG3-knockout mice.
We recently identified BIG3 as a negative regulator of insulin granule biogenesis and reported increased insulin secretion in… 
Review
2012
Review
2012
On WD40 proteins: Propelling our knowledge of transcriptional control?
A direct effect of post-translational modifications (PTMs) on nucleosomes is the formation of a dynamic platform able to assemble… 
2008
2008
Interacts with Mixed Lineage Leukemia ( MLL ) Protein via the Histone H 3-binding Pocket *
WDR5 is a component of the mixed lineage leukemia (MLL) complex, whichmethylates lysine 4 of histoneH3, andwas identified as a… 
2005
2005
Defining epigenetic states through chromatin and RNA
The term ‘epigenetics’ is used to describe heritable changes in genome function that occur without a change in DNA sequence. As… 
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