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Mechanisms of Polycomb gene silencing: knowns and unknowns
Polycomb proteins form chromatin-modifying complexes that implement transcriptional silencing in higher eukaryotes. Hundreds of genes are silenced by Polycomb proteins, including dozens of genes thatExpand
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Stabilization of Chromatin Structure by PRC1, a Polycomb Complex
The Polycomb group (PcG) genes are required for maintenance of homeotic gene repression during development. Mutations in these genes can be suppressed by mutations in genes of the SWI/SNF family. WeExpand
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Genome-wide identification of polycomb-associated RNAs by RIP-seq.
Polycomb proteins play essential roles in stem cell renewal and human disease. Recent studies of HOX genes and X inactivation have provided evidence for RNA cofactors in Polycomb repressive complex 2Expand
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Cooperation between Complexes that Regulate Chromatin Structure and Transcription
Chromatin structure creates barriers for each step in eukaryotic transcription. Here we discuss how the activities of two major classes of chromatin-modifying complexes, ATP-dependent remodelingExpand
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Histone Methyltransferase Activity of a Drosophila Polycomb Group Repressor Complex
Polycomb group (PcG) proteins maintain transcriptional repression during development, likely by creating repressive chromatin states. The Extra Sex Combs (ESC) and Enhancer of Zeste [E(Z)] proteinsExpand
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The ENCODE (ENCyclopedia Of DNA Elements) Project
The ENCyclopedia Of DNA Elements (ENCODE) Project aims to identify all functional elements in the human genome sequence. The pilot phase of the Project is focused on a specified 30 megabases (∼1%) ofExpand
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A Drosophila Polycomb group complex includes Zeste and dTAFII proteins
A goal of modern biology is to identify the physical interactions that define ‘functional modules’ of proteins that govern biological processes. One essential regulatory process is the maintenance ofExpand
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Alteration of nucleosome structure as a mechanism of transcriptional regulation.
The nucleosome, which is the primary building block of chromatin, is not a static structure: It can adopt alternative conformations. Changes in solution conditions or changes in histone acetylationExpand
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Characterization of the piRNA Complex from Rat Testes
Small noncoding RNAs regulate processes essential for cell growth and development, including mRNA degradation, translational repression, and transcriptional gene silencing (TGS). During a search forExpand
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Chromatin Compaction by a Polycomb Group Protein Complex
Polycomb group proteins preserve body patterning through development by maintaining transcriptional silencing of homeotic genes. A long-standing hypothesis is that silencing involves creatingExpand
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