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WASF2 gene

Known as: SCAR2, WAS protein family member 2, WASP FAMILY, VERPROLIN HOMOLOGY DOMAIN-CONTAINING PROTEIN 2 
This gene is involved in both the mediation of signal transduction and the regulation of cytoskeletal reorganization.
National Institutes of Health

Related topics

Related topics

4 relations
Cytoskeletal ModelingSignal TransductionWASF2 protein, humanWASF3 gene

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2013
Highly Cited
2013
MicroRNA-146a acts as a metastasis suppressor in gastric cancer by targeting WASF2.
Previous studies have shown that miR-146a acts as either an oncogene or a tumor suppressor in various cancers. In this study, we… Expand
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Highly Cited
2011
Highly Cited
2011
ERK-MAPK drives lamellipodia protrusion by activating the WAVE2 regulatory complex.
Cell movement begins with a leading edge protrusion, which is stabilized by nascent adhesions and retracted by mature adhesions… Expand
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Highly Cited
2008
Highly Cited
2008
WASP family members and formin proteins coordinate regulation of cell protrusions in carcinoma cells
We examined the role of the actin nucleation promoters neural Wiskott-Aldrich syndrome protein (N-WASP) and WAVE2 in cell… Expand
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Highly Cited
2006
Highly Cited
2006
Optimization of WAVE2 complex–induced actin polymerization by membrane-bound IRSp53, PIP3, and Rac
WAVE2 activates the actin-related protein (Arp) 2/3 complex for Rac-induced actin polymerization during lamellipodium formation… Expand
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Highly Cited
2006
Highly Cited
2006
Rac-WAVE-mediated actin reorganization is required for organization and maintenance of cell-cell adhesion.
During cadherin-dependent cell-cell adhesion, the actin cytoskeleton undergoes dynamic reorganization in epithelial cells. Rho… Expand
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2005
2005
WAVE2 signaling mediates invasion of polarized epithelial cells by Salmonella typhimurium.
The bacterial pathogen Salmonella penetrates the intestinal epithelium by inducing its own phagocytosis into epithelial cells… Expand
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Highly Cited
2004
Highly Cited
2004
PtdIns(3,4,5)P3 binding is necessary for WAVE2-induced formation of lamellipodia
Polarized cell movement is triggered by the development of a PtdIns(3,4,5)P3 gradient at the membrane, which is followed by… Expand
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Highly Cited
2004
Highly Cited
2004
Abi1 is essential for the formation and activation of a WAVE2 signalling complex
WAVE2 belongs to a family of proteins that mediates actin reorganization by relaying signals from Rac to the Arp2/3 complex… Expand
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Highly Cited
2003
Highly Cited
2003
The molecular nature of the zebrafish tail organizer
Based on grafting experiments, Mangold and Spemann showed the dorsal blastopore lip of an amphibian gastrula to be able to induce… Expand
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2002
2002
WAVE2 serves a functional partner of IRSp53 by regulating its interaction with Rac.
We previously reported that IRSp53 binds both Rac and WAVE2, inducing formation of Rac/IRSp53/WAVE2 complex that is important for… Expand
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