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WASF2 gene

Known as: SCAR2, WAS protein family member 2, WASP FAMILY, VERPROLIN HOMOLOGY DOMAIN-CONTAINING PROTEIN 2 
This gene is involved in both the mediation of signal transduction and the regulation of cytoskeletal reorganization.
National Institutes of Health

Related topics

Related topics

4 relations
Cytoskeletal ModelingSignal TransductionWASF2 protein, humanWASF3 gene

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2011
Highly Cited
2011
ERK-MAPK drives lamellipodia protrusion by activating the WAVE2 regulatory complex.
Cell movement begins with a leading edge protrusion, which is stabilized by nascent adhesions and retracted by mature adhesions… Expand
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Highly Cited
2008
Highly Cited
2008
WASP family members and formin proteins coordinate regulation of cell protrusions in carcinoma cells
We examined the role of the actin nucleation promoters neural Wiskott-Aldrich syndrome protein (N-WASP) and WAVE2 in cell… Expand
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Highly Cited
2007
Highly Cited
2007
Rac-WAVE-mediated actin reorganization is required for organization and maintenance of cell-cell adhesion
During cadherin-dependent cell-cell adhesion, the actin cytoskeleton undergoes dynamic reorganization in epithelial cells. Rho… Expand
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Highly Cited
2006
Highly Cited
2006
Optimization of WAVE2 complex–induced actin polymerization by membrane-bound IRSp53, PIP3, and Rac
WAVE2 activates the actin-related protein (Arp) 2/3 complex for Rac-induced actin polymerization during lamellipodium formation… Expand
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Highly Cited
2005
Highly Cited
2005
Abelson-interactor-1 promotes WAVE2 membrane translocation and Abelson-mediated tyrosine phosphorylation required for WAVE2 activation.
WAVE2 is a member of the Wiskott-Aldrich syndrome protein family of cytoskeletal regulatory proteins shown to link Rac activation… Expand
Highly Cited
2004
Highly Cited
2004
PtdIns(3,4,5)P3 binding is necessary for WAVE2-induced formation of lamellipodia
Polarized cell movement is triggered by the development of a PtdIns(3,4,5)P3 gradient at the membrane, which is followed by… Expand
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Highly Cited
2004
Highly Cited
2004
Abi1 is essential for the formation and activation of a WAVE2 signalling complex
WAVE2 belongs to a family of proteins that mediates actin reorganization by relaying signals from Rac to the Arp2/3 complex… Expand
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Highly Cited
2003
Highly Cited
2003
WAVE2 is required for directed cell migration and cardiovascular development
WAVE2, a protein related to Wiskott–Aldrich syndrome protein, is crucial for Rac-induced membrane ruffling, which is important in… Expand
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Highly Cited
2003
Highly Cited
2003
WAVE2 deficiency reveals distinct roles in embryogenesis and Rac‐mediated actin‐based motility
The Wiskott–Aldrich syndrome related protein WAVE2 is implicated in the regulation of actin‐cytoskeletal reorganization… Expand
Highly Cited
2003
Highly Cited
2003
The molecular nature of the zebrafish tail organizer
Based on grafting experiments, Mangold and Spemann showed the dorsal blastopore lip of an amphibian gastrula to be able to induce… Expand
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