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WASF2 gene
Known as:
SCAR2
, WAS protein family member 2
, WASP FAMILY, VERPROLIN HOMOLOGY DOMAIN-CONTAINING PROTEIN 2
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This gene is involved in both the mediation of signal transduction and the regulation of cytoskeletal reorganization.
National Institutes of Health
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Related topics
Related topics
4 relations
Cytoskeletal Modeling
Signal Transduction
WASF2 protein, human
WASF3 gene
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2011
Highly Cited
2011
ERK-MAPK drives lamellipodia protrusion by activating the WAVE2 regulatory complex.
Michelle C. Mendoza
,
E. Er
,
+4 authors
J. Blenis
Molecular cell
2011
Corpus ID: 10812931
Highly Cited
2008
Highly Cited
2008
WASP family members and formin proteins coordinate regulation of cell protrusions in carcinoma cells
C. Sarmiento
,
Weigang Wang
,
+9 authors
J. Condeelis
The Journal of cell biology
2008
Corpus ID: 8296590
We examined the role of the actin nucleation promoters neural Wiskott-Aldrich syndrome protein (N-WASP) and WAVE2 in cell…
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Highly Cited
2007
Highly Cited
2007
Rac-WAVE-mediated actin reorganization is required for organization and maintenance of cell-cell adhesion
D. Yamazaki
,
T. Oikawa
,
T. Takenawa
Journal of Cell Science
2007
Corpus ID: 25451829
During cadherin-dependent cell-cell adhesion, the actin cytoskeleton undergoes dynamic reorganization in epithelial cells. Rho…
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Highly Cited
2006
Highly Cited
2006
Optimization of WAVE2 complex–induced actin polymerization by membrane-bound IRSp53, PIP3, and Rac
S. Suetsugu
,
S. Kurisu
,
T. Oikawa
,
D. Yamazaki
,
A. Oda
,
T. Takenawa
The Journal of cell biology
2006
Corpus ID: 16143875
WAVE2 activates the actin-related protein (Arp) 2/3 complex for Rac-induced actin polymerization during lamellipodium formation…
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Highly Cited
2005
Highly Cited
2005
Abelson-interactor-1 promotes WAVE2 membrane translocation and Abelson-mediated tyrosine phosphorylation required for WAVE2 activation.
Y. Leng
,
Jinyi Zhang
,
+5 authors
K. Siminovitch
Proceedings of the National Academy of Sciences…
2005
Corpus ID: 38016330
WAVE2 is a member of the Wiskott-Aldrich syndrome protein family of cytoskeletal regulatory proteins shown to link Rac activation…
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Highly Cited
2004
Highly Cited
2004
PtdIns(3,4,5)P3 binding is necessary for WAVE2-induced formation of lamellipodia
T. Oikawa
,
H. Yamaguchi
,
+5 authors
T. Takenawa
Nature Cell Biology
2004
Corpus ID: 26828305
Polarized cell movement is triggered by the development of a PtdIns(3,4,5)P3 gradient at the membrane, which is followed by…
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Highly Cited
2004
Highly Cited
2004
Abi1 is essential for the formation and activation of a WAVE2 signalling complex
M. Innocenti
,
A. Zucconi
,
+7 authors
G. Scita
Nature Cell Biology
2004
Corpus ID: 22767022
WAVE2 belongs to a family of proteins that mediates actin reorganization by relaying signals from Rac to the Arp2/3 complex…
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Highly Cited
2003
Highly Cited
2003
WAVE2 deficiency reveals distinct roles in embryogenesis and Rac‐mediated actin‐based motility
Catherine T. Yan
,
N. Martinez-Quiles
,
+10 authors
F. Alt
The EMBO journal
2003
Corpus ID: 21186587
The Wiskott–Aldrich syndrome related protein WAVE2 is implicated in the regulation of actin‐cytoskeletal reorganization…
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Highly Cited
2003
Highly Cited
2003
WAVE2 is required for directed cell migration and cardiovascular development
D. Yamazaki
,
S. Suetsugu
,
+5 authors
T. Takenawa
Nature
2003
Corpus ID: 4389503
WAVE2, a protein related to Wiskott–Aldrich syndrome protein, is crucial for Rac-induced membrane ruffling, which is important in…
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Highly Cited
2003
Highly Cited
2003
The molecular nature of the zebrafish tail organizer
A. Agathon
,
C. Thisse
,
B. Thisse
Nature
2003
Corpus ID: 4337123
Based on grafting experiments, Mangold and Spemann showed the dorsal blastopore lip of an amphibian gastrula to be able to induce…
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