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Vepoloxamer

A purified form of the non-ionic polyoxypropylene-based copolymer poloxamer 188 comprised of a hydrophobic core with hydrophilic side chains, with… 
National Institutes of Health

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Purified Poloxamer 188

Papers overview

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2020
2020
Effects of Intravenous Infusion of Vepoloxamer on Left Ventricular Function in Dogs with Advanced Heart Failure
Purpose Vepoloxamer (VEPO), a rheologic agent, repairs damaged cell membranes, thus inhibiting unregulated Ca 2+ entry into… 
2017
2017
The purified vepoloxamer prevents haemolysis in 42-day stored, DEHP/PVC-free red blood cell units.
BACKGROUND Use of the plasticiser di(2-ethylhexyl) phthalate (DEHP) in polyvinyl chloride (PVC) blood bags poses a potential… 
Review
2016
Review
2016
The Pharmacologic Rationale Supporting the Potential Use of Vepoloxamer for the Treatment of Acute Chest Syndrome in Patients with Sickle Cell Disease
Sickle Cell Disease (SCD) is an autosomal recessive disorder caused by a single amino acid substitution in the Hemoglobin (Hb… 
2016
2016
Vepoloxamer (Purified Poloxamer-188) Restores Integrity of Cardiomyocyte Calcium Cycling Proteins in Left Ventricular Myocardium of Dogs With Advanced Heart Failure
2015
2015
Evaluation of Purified Poloxamer-188 (vepoloxamer) on Sickle Red Blood Cell (RBC) Membrane Function Properties
Background: Sickle erythrocyte adhesion and membrane fragility contribute to vaso-occlusion and downstream tissue and organ… 
2015
2015
In-Vitro Exposure of Isolated Failing Cardiomyocytes to Vepoloxamer (Purified Poloxamer 188) Limits Unregulated Calcium Entry into the Cell
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