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Novel, ultraslow inactivating sodium current in human ventricular cardiomyocytes.
- V. Maltsev, H. Sabbah, R. Higgins, N. Silverman, M. Lesch, A. Undrovinas
- 8 December 1998
BACKGROUND Alterations in K+ channel expression and gating are thought to be the major cause of action potential remodeling in heart failure (HF). We previously reported the existence of a late Na+… Expand
Cardiac mitochondria in heart failure: decrease in respirasomes and oxidative phosphorylation
- Mariana G Rosca, Edwin J. Vazquez, +5 authors C. Hoppel
- Medicine, Biology
- Cardiovascular research
- 18 August 2008
Aims Mitochondrial dysfunction is a major factor in heart failure (HF). A pronounced variability of mitochondrial electron transport chain (ETC) defects is reported to occur in severe acquired… Expand
Effects of angiotensin-converting enzyme inhibitors and angiotensin II type 1 receptor antagonists in rats with heart failure. Role of kinins and angiotensin II type 2 receptors.
- Y. Liu, X. P. Yang, +4 authors O. Carretero
- Chemistry, Medicine
- The Journal of clinical investigation
- 15 April 1997
Angiotensin-converting enzyme inhibitors (ACEi) improve cardiac function and remodeling and prolong survival in patients with heart failure (HF). Blockade of the renin-angiotensin system (RAS) with… Expand
Parasympathetic nervous system and heart failure: pathophysiology and potential implications for therapy.
Abundant evidence links sympathetic nervous system activation to outcomes of patients with heart failure (HF).1 In contrast, parasympathetic activation has complex cardiovascular effects that are… Expand
Ranolazine Improves Abnormal Repolarization and Contraction in Left Ventricular Myocytes of Dogs with Heart Failure by Inhibiting Late Sodium Current
- A. Undrovinas, L. Belardinelli, N. A. Undrovinas, H. Sabbah
- Journal of cardiovascular electrophysiology
- 1 May 2006
Background: Ventricular repolarization and contractile function are frequently abnormal in ventricular myocytes from human failing hearts as well as canine hearts with experimentally induced heart… Expand
Chronic heart failure slows late sodium current in human and canine ventricular myocytes: Implications for repolarization variability
- V. Maltsev, N. Silverman, H. Sabbah, A. Undrovinas
- European journal of heart failure
- 1 March 2007
Late Na+ current (INaL) in human and dog hearts has been implicated in abnormal repolarization associated with heart failure (HF). HF slows inactivation gating of late Na+ channels, which could… Expand
Developing therapies for heart failure with preserved ejection fraction: current state and future directions.
The burden of heart failure with preserved ejection fraction (HFpEF) is considerable and is projected to worsen. To date, there are no approved therapies available for reducing mortality or… Expand
Mitochondrial function as a therapeutic target in heart failure
- D. Brown, Justin B. Perry, +13 authors M. Gheorghiade
- Nature Reviews Cardiology
- 22 December 2016
Heart failure is a pressing worldwide public-health problem with millions of patients having worsening heart failure. Despite all the available therapies, the condition carries a very poor prognosis.… Expand
Ultrastructural and light microscopic evidence of apoptosis after middle cerebral artery occlusion in the rat.
- Y. Li, Victor G. Sharov, N. Jiang, C. Zaloga, H. Sabbah, M. Chopp
- Biology, Medicine
- The American journal of pathology
- 1 May 1995
Brains from eight rats subjected to transient focal ischemia (2 hours) and reperfusion (22 hours) revealed an ultrastructural appearance of apoptosis and light microscopic features of cells… Expand
Therapy with cardiac contractility modulation electrical signals improves left ventricular function and remodeling in dogs with chronic heart failure.
- Makoto Imai, S. Rastogi, +8 authors H. Sabbah
- Journal of the American College of Cardiology
- 29 May 2007
OBJECTIVES This study examined the effects of long-term delivery of cardiac contractility modulation (CCM) electric signals on left ventricular (LV) function and global, cellular, and molecular… Expand