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VX 809

Known as: VX-809 
National Institutes of Health

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1 relation

Broader (1)

lumacaftor

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2020
2020
iPSC-Derived Intestinal Organoids from Cystic Fibrosis Patients Acquire CFTR Activity upon TALEN-Mediated Repair of the p.F508del Mutation
2019
2019
Evaluation of 1,2,3-Triazoles as Amide Bioisosteres In Cystic Fibrosis Transmembrane Conductance Regulator Modulators VX-770 and VX-809.
The 1,2,3-triazole has been successfully utilized as an amide bioisostere in multiple therapeutic contexts. Based on this… 
Highly Cited
2018
Highly Cited
2018
Lumacaftor (VX-809) restores the ability of CF macrophages to phagocytose and kill Pseudomonas aeruginosa.
Cystic fibrosis (CF), the most common lethal genetic disease in Caucasians, is characterized by chronic bacterial lung infection… 
Highly Cited
2017
Highly Cited
2017
Pharmacological Rescue of Conditionally Reprogrammed Cystic Fibrosis Bronchial Epithelial Cells
&NA; Well‐differentiated primary human bronchial epithelial (HBE) cell cultures are vital for cystic fibrosis (CF) research… 
2016
2016
The investigational Cystic Fibrosis drug Trimethylangelicin directly modulates CFTR by stabilizing the first membrane-spanning domain.
Highly Cited
2015
Highly Cited
2015
Pseudomonas aeruginosa Reduces VX-809 Stimulated F508del-CFTR Chloride Secretion by Airway Epithelial Cells
Background P. aeruginosa is an opportunistic pathogen that chronically infects the lungs of 85% of adult patients with Cystic… 
2015
2015
Increased efficacy of VX-809 in different cellular systems results from an early stabilization effect of F508del-CFTR
Cystic fibrosis (CF), the most common recessive autosomal disease among Caucasians, is caused by mutations in the gene encoding… 
2015
2015
Genetic Inhibition Of The Ubiquitin Ligase Rnf5 Attenuates Phenotypes Associated To F508del Cystic Fibrosis Mutation
Cystic fibrosis (CF) is caused by mutations in the CFTR chloride channel. Deletion of phenylalanine 508 (F508del), the most… 
Highly Cited
2014
Highly Cited
2014
SYNERGY-BASED SMALL-MOLECULE SCREEN USING A HUMAN LUNG EPITHELIAL CELL LINE F508-CFTR CORRECTORS THAT AUGMENT VX-809 MAXIMAL EFFICACY
The most prevalent CFTR mutation causing cystic fibrosis, Δ F508, impairs folding of nucleotide binding domain 1 (NBD1) and… 
Review
2013
Review
2013
Development, clinical utility, and place of ivacaftor in the treatment of cystic fibrosis
Cystic fibrosis (CF) is a life-limiting, multisystem disease characterized by thick viscous secretions leading to recurrent lung… 
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