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VX 478

Known as: KVX 478, VX-478, Vertex VX478 
 
National Institutes of Health

Papers overview

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Review
2012
Review
2012
SummaryThe HIV protease (or proteinase) enzyme is an essential component of the replicative cycle of HIV, performing the post… Expand
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Highly Cited
1998
Highly Cited
1998
Amprenavir (141W94, VX-478, KVX-478) is metabolized primarily by CYP3A4 (cytochrome P450 3A4) in recombinant systems and human… Expand
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1998
1998
To combat infection and inhibit viral replication of HIV in the brain, antiretroviral agents must cross the blood-brain barrier… Expand
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Highly Cited
1997
Highly Cited
1997
Coadministration with the human immunodeficiency virus (HIV) protease inhibitor ritonavir was investigated as a method for… Expand
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Review
1997
Review
1997
SummarySince its introduction in 1987, zidovudine monotherapy has been the treatment of choice for patients with HIV infection… Expand
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1996
1996
141W94 (VX-478) is a novel HIV-1 protease inhibitor with an IC50 of 0.08 microM against HIV-1 (strain IIIB) and a mean IC50 of 0… Expand
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1996
1996
Compound 141W94 (Vertex VX478) (3S)-tetrahydro-3-furyl N-[((S,2R)-3-(4-amino-N-isobutylbenzenesulfonamido)-1-benzyl- 2… Expand
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1996
1996
Mutations in the human immunodeficiency virus (HIV) protease (L90M, G48V, and L90M/G48V) arise when HIV is passaged in the… Expand
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1995
1995
VX-478 is a potent inhibitor of human immunodeficiency virus type 1 (HIV-1) protease (Ki, 0.6 nM) and of HIV-1 replication in… Expand
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Highly Cited
1995
Highly Cited
1995
Human immunodeficiency virus type 1 (HIV-1) variants with reduced sensitivity to the hydroxyethylamino sulfonamide protease… Expand
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