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VX 478

Known as: KVX 478, VX-478, Vertex VX478 
National Institutes of Health

Papers overview

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2001
2001
Two studies, concerning the synthesis of original nucleoside analogs regarded as an application of heterochemistry on… 
2000
2000
HIV protease catalyzes the hydrolysis of specific peptide bonds of viral polyproteins, thus processing these polyproteins into… 
1998
1998
Recent experimental findings with HIV-1 protease (HIV-1 PR) mutants containing variations at four residues, M46I, L63P, V82T and… 
1998
1998
  • D. Fakuda
  • 1998
  • Corpus ID: 11721742
There are a number of new developments in the fight against the HIV epidemic. New drugs are being developed, results are being… 
1996
1996
Compound 141W94 (Vertex VX478) (3S)-tetrahydro-3-furyl N-[((S,2R)-3-(4-amino-N-isobutylbenzenesulfonamido)-1-benzyl- 2… 
Highly Cited
1996
Highly Cited
1996
Passage of human immunodeficiency virus type-1 (HIV-1) in T-lymphocyte cell lines in the presence of increasing concentrations of… 
Review
1996
Review
1996
AIM To review drug-resistance patterns of HIV protease inhibitors, with particular reference to saquinavir, and how resistance… 
Highly Cited
1995
Highly Cited
1995
VX-478 is a potent inhibitor of human immunodeficiency virus type 1 (HIV-1) protease (Ki, 0.6 nM) and of HIV-1 replication in… 
1995
1995
New clinical trial developments surrounding anti-HIV compounds, known as protease inhibitors, are discussed for the following…