VPREB1 gene

TCF3-HLF−positive acute lymphoblastic leukemia (ALL) is currently incurable. Using an integrated approach, we uncovered distinct… Expand

Children with Down’s syndrome (DS) have an increased risk of developing acute lymphoblastic leukemia (ALL) and have a low… Expand

Signals delivered by the immunoglobulin (Ig)-like pre-B-cell receptor (pre-BCR) are critical for efficient maturation of early… Expand

B lymphocyte development is a complex biological process critically dependent on the transcription factor early B cell factor… Expand

The pre-B cell receptor consists of immunoglobulin (Ig) mu heavy chains and surrogate light chain, i.e., the VpreB and lambda5… Expand

Surrogate light chain, which escorts the mu heavy chain to the cell surface, is a critical component of the pre-B cell receptor… Expand

Normally occurring and experimentally induced models of immunodeficiency indicate that B cell development and antibody production… Expand

The VpreB and lambda 5 genes encode proteins that associate non-covalently to form the so-called surrogate light (SL) chain. The… Expand

The surrogate light chain is composed of two polypeptides, VpreB and lambda 5. In the mouse there are two VpreB genes which are… Expand

In human preB cells, the mu chain is associated with a surrogate light chain composed of the VpreB and lambda-like gene products… Expand