VPREB1 gene

The VpreB component of the surrogate light chain serves as an invariant antigen that may affect the repertoire of antibody… Expand

Signals delivered by the immunoglobulin (Ig)-like pre-B-cell receptor (pre-BCR) are critical for efficient maturation of early… Expand

The pre-B cell receptor (pre-BCR) is composed of the immunoglobulin (Ig) heavy (microH) chain and the surrogate light chain… Expand

The development of mature B lymphoid cells involves a highly orchestrated regulation of stage- and lineage-specific genes. In… Expand

The pre-B cell receptor consists of immunoglobulin (Ig) μ heavy chains and surrogate light chain, i.e., the VpreB and λ5 proteins… Expand

Surrogate light chain, which escorts the mu heavy chain to the cell surface, is a critical component of the pre-B cell receptor… Expand

The surrogate light chain (SL) composed of the A-like and VpreB polypeptides is organized as two Ig domains and an extra-loop… Expand

The VpreB and λ5 genes encode proteins that associate non‐covalently to form the so‐called surrogate light (SL) chain. The SL… Expand

We describe the molecular components, subunit assembly, and cell surface expression of mu-chain complexes in mu+kappa- pre-B cell… Expand

In human preB cells, the mu chain is associated with a surrogate light chain composed of the VpreB and lambda-like gene products… Expand