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VPRBP wt Allele

Known as: KIAA0800, MGC102804, DCAF1 
Human VPRBP wild-type allele is located in the vicinity of 3p21.2 and is approximately 101 kb in length. This allele, which encodes protein VPRBP, is… 
National Institutes of Health

Papers overview

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2018
2018
DCAF1 is involved in HCV replication through regulation of miR-122
Hepatitis C virus (HCV) is a worldwide threaten to human health with a high ratio of chronic infections. Recently, we found that… 
2016
2016
HIV-1 Vpr increases HCV replication through VprBP in cell culture.
2014
2014
Defining the Interactions and Role of DCAF1/VPRBP in the DDB1-Cullin4A E3 Ubiquitin Ligase Complex Engaged by HIV-1 Vpr to Induce a G2 Cell Cycle Arrest
HIV viral protein R (Vpr) induces a cell cycle arrest at the G2/M phase by activating the ATR DNA damage/replication stress… 
2014
2014
Structural basis of DDB1‐and‐Cullin 4‐associated Factor 1 (DCAF1) recognition by merlin/NF2 and its implication in tumorigenesis by CD44‐mediated inhibition of merlin suppression of DCAF1 function
Merlin, a tumor suppressor encoded by the neurofibromatosis type 2 gene, has been shown to suppress tumorigenesis by inhibiting… 
2013
2013
Reprogramming by Activation of TET Proteins CRL 4 Complex Regulates Mammalian Oocyte Survival and
, 1518 (2013); 342 Science et al. Chao Yu Reprogramming by Activation of TET Proteins CRL4 Complex Regulates Mammalian Oocyte… 
2012
2012
Evidence for Vpr-dependent HIV-1 Replication in Human CD4+ CEM.NKR T-Cells
BackgroundVpr is exclusively expressed in primate lentiviruses and contributes to viral replication and disease progression in… 
2012
2012
Evidence for Vpr-dependent HIV-1 Replication in Human CD4+CEM.NKR T-Cells
Vpr is exclusively expressed in primate lentiviruses and contributes to viral replication and disease progression in vivo. HIV-1… 
2012
2012
Interaction of Two HIV Protein Paralogues with DCAF1 and Cyclin L2
is published by the Office of Undergraduate Research once a semester each academic year. Applications for submission and… 
2011
2011
HIV: Going for the watchman
A protein called SAMHD1 seems to hinder the infection of key cells of the immune system by HIV-1. Cousins of this virus, however… 
Review
2009
Review
2009
Structure-function relationship of Vpr: biological implications.
Vpr, incorporated into the HIV-1 virion, shows multiple activities including nuclear transport of the preintegration complex to… 
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