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VPC23019

 
National Institutes of Health

Related topics

Related topics

2 relations

Broader (1)

Phosphoserine
analogs & derivatives

Papers overview

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Highly Cited
2012
Highly Cited
2012
Isoflurane attenuates blood-brain barrier disruption in ipsilateral hemisphere after subarachnoid hemorrhage in mice.
BACKGROUND AND PURPOSE We examined effects of isoflurane, volatile anesthetics, on blood-brain barrier disruption in the… Expand
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Highly Cited
2010
Highly Cited
2010
Activation of sphingosine 1-phosphate receptor-1 by FTY720 is neuroprotective after ischemic stroke in rats.
BACKGROUND AND PURPOSE FTY720 is a known sphingosine 1-phosphate receptor agonist. In the present study, we investigated the… Expand
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Highly Cited
2010
Highly Cited
2010
Sphingosine 1-Phosphate (S1P) Regulates Vascular Contraction via S1P3 Receptor: Investigation Based on a New S1P3 Receptor Antagonist
Sphingosine 1-phosphate (S1P) induces diverse biological responses in various tissues by activating specific G protein-coupled… Expand
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Highly Cited
2010
Highly Cited
2010
Isoflurane posttreatment reduces neonatal hypoxic-ischemic brain injury in rats by the sphingosine-1-phosphate/phosphatidylinositol-3-kinase/Akt pathway.
BACKGROUND AND PURPOSE Isoflurane, administered before or during cerebral ischemia, has been shown to exhibit neuroprotection in… Expand
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Highly Cited
2009
Highly Cited
2009
Hypoxia enhances sphingosine kinase 2 activity and provokes sphingosine-1-phosphate-mediated chemoresistance in A549 lung cancer cells.
Hypoxia and signaling via hypoxia-inducible factor-1 (HIF-1) is a key feature of solid tumors and is related to tumor progression… Expand
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Highly Cited
2008
Highly Cited
2008
Analysis of sphingosine 1-phosphate receptors involved in constriction of isolated cerebral arteries with receptor null mice and pharmacological tools.
BACKGROUND AND PURPOSE Sphingosine 1-phosphate (S1P) selectively and potently constricts isolated cerebral arteries, but this… Expand
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Highly Cited
2008
Highly Cited
2008
HDL-associated lysosphingolipids inhibit NAD(P)H oxidase-dependent monocyte chemoattractant protein-1 production.
OBJECTIVE High-density lipoprotein (HDL) levels are inversely proportional to the risk of atherosclerosis, but mechanisms of HDL… Expand
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Highly Cited
2007
Highly Cited
2007
Deletion of the sphingosine kinase-1 gene influences cell fate during hypoxia and glucose deprivation in adult mouse cardiomyocytes.
OBJECTIVES Activation of sphingosine kinase (SphK), which has two known isoforms, is responsible for the synthesis of sphingosine… Expand
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Highly Cited
2007
Highly Cited
2007
Essential roles of sphingosine 1-phosphate/S1P1 receptor axis in the migration of neural stem cells toward a site of spinal cord injury.
Neural stem/progenitor cells (NSPCs) migrate toward a damaged area of the central nervous system (CNS) for the purpose of… Expand
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Highly Cited
2005
Highly Cited
2005
Sphingosine 1-phosphate analogs as receptor antagonists.
Sphingosine 1-phosphate (S1P) is a lysophospholipid mediator that evokes a variety of cell and tissue responses via a set of cell… Expand
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