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VPC 12249

Known as: VPC-12249, VPC12249 
 
National Institutes of Health

Papers overview

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2014
2014
Lysophosphatidic Acid Receptor Type 1 (LPA1) Plays a Functional Role in Osteoclast Differentiation and Bone Resorption Activity*
Background: Lysophosphatidic acid (LPA) is a bioactive lipid with pleiotropic activities due to activation of six receptors (LPA1… Expand
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2014
2014
Regulation of silicosis formation by lysophosphatidic acid and its receptors
ABSTRACT Silicosis is a serious occupational disease characterized by lung fibrosis that is caused by long-term inhalation of… Expand
2013
2013
Temporal expression of hippocampal lysophosphatidic acid receptors and their roles in kainic acid-induced neurotoxicity
In this investigation, the role of hippocampal lysophosphatidic acid (LPA) receptors in the regulation of kainic acid (KA… Expand
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Highly Cited
2011
Highly Cited
2011
Blockade of lysophosphatidic acid receptors LPAR1/3 ameliorates lung fibrosis induced by irradiation.
Lung fibrosis is a common and serious complication of radiation therapy for lung cancer, for which there are no efficient… Expand
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2010
2010
Effects of lysophosphatidic acid and its receptors LPA⅓ on radiation pneumonitis.
Radiation pneumonitis (RP) is a serious complication of radiation therapy for thoracic tumors. Lysophosphatidic acid (LPA) and… Expand
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2008
2008
Mechanisms of the lysophosphatidic acid-induced increase in [Ca2+]i in skeletal muscle cells
Although lysophosphatidic acid (LPA) is known to increase intracellularfree calcium concentration ([Ca2+]i) in different cell… Expand
Highly Cited
2004
Highly Cited
2004
Initial structure-activity relationships of lysophosphatidic acid receptor antagonists: discovery of a high-affinity LPA1/LPA3 receptor antagonist.
A recently reported dual LPA1/LPA3 receptor antagonist (VPC12249, 1) has been modified herein so as to optimize potency and… Expand
Highly Cited
2003
Highly Cited
2003
Identification of a Phosphothionate Analogue of Lysophosphatidic Acid (LPA) as a Selective Agonist of the LPA3 Receptor*
Lysophosphatidic acid (LPA) is a bioactive lysophospholipid mediator that acts through G protein-coupled receptors. Most cell… Expand
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Highly Cited
2003
Highly Cited
2003
Selective blockade of lysophosphatidic acid LPA3 receptors reduces murine renal ischemia-reperfusion injury.
Lysophosphatidic acid (LPA) released during ischemia has diverse physiological effects via its G protein-coupled receptors, LPA1… Expand
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Highly Cited
2001
Highly Cited
2001
Activity of 2-substituted lysophosphatidic acid (LPA) analogs at LPA receptors: discovery of a LPA1/LPA3 receptor antagonist.
The physiological implications of lysophosphatidic acid occupancy of individual receptors are largely unknown because selective… Expand
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