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VPC 12249

Known as: VPC-12249, VPC12249 
 
National Institutes of Health

Papers overview

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2014
2014
Background: Lysophosphatidic acid (LPA) is a bioactive lipid with pleiotropic activities due to activation of six receptors (LPA1… Expand
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2014
2014
ABSTRACT Silicosis is a serious occupational disease characterized by lung fibrosis that is caused by long-term inhalation of… Expand
2013
2013
In this investigation, the role of hippocampal lysophosphatidic acid (LPA) receptors in the regulation of kainic acid (KA… Expand
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Highly Cited
2011
Highly Cited
2011
Lung fibrosis is a common and serious complication of radiation therapy for lung cancer, for which there are no efficient… Expand
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2010
2010
Radiation pneumonitis (RP) is a serious complication of radiation therapy for thoracic tumors. Lysophosphatidic acid (LPA) and… Expand
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2008
2008
Although lysophosphatidic acid (LPA) is known to increase intracellularfree calcium concentration ([Ca2+]i) in different cell… Expand
Highly Cited
2004
Highly Cited
2004
A recently reported dual LPA1/LPA3 receptor antagonist (VPC12249, 1) has been modified herein so as to optimize potency and… Expand
Highly Cited
2003
Highly Cited
2003
Lysophosphatidic acid (LPA) is a bioactive lysophospholipid mediator that acts through G protein-coupled receptors. Most cell… Expand
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Highly Cited
2003
Highly Cited
2003
Lysophosphatidic acid (LPA) released during ischemia has diverse physiological effects via its G protein-coupled receptors, LPA1… Expand
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Highly Cited
2001
Highly Cited
2001
The physiological implications of lysophosphatidic acid occupancy of individual receptors are largely unknown because selective… Expand
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