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VPC 12249

Known as: VPC-12249, VPC12249 
National Institutes of Health

Papers overview

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2014
2014
Lysophosphatidic Acid Receptor Type 1 (LPA1) Plays a Functional Role in Osteoclast Differentiation and Bone Resorption Activity*
Background: Lysophosphatidic acid (LPA) is a bioactive lipid with pleiotropic activities due to activation of six receptors (LPA1… 
2014
2014
Regulation of silicosis formation by lysophosphatidic acid and its receptors
ABSTRACT Silicosis is a serious occupational disease characterized by lung fibrosis that is caused by long-term inhalation of… 
2013
2013
Temporal expression of hippocampal lysophosphatidic acid receptors and their roles in kainic acid-induced neurotoxicity
In this investigation, the role of hippocampal lysophosphatidic acid (LPA) receptors in the regulation of kainic acid (KA… 
Highly Cited
2011
Highly Cited
2011
Blockade of lysophosphatidic acid receptors LPAR1/3 ameliorates lung fibrosis induced by irradiation.
2010
2010
Effects of lysophosphatidic acid and its receptors LPA⅓ on radiation pneumonitis.
Radiation pneumonitis (RP) is a serious complication of radiation therapy for thoracic tumors. Lysophosphatidic acid (LPA) and… 
2008
2008
Mechanisms of the lysophosphatidic acid-induced increase in [Ca2+]i in skeletal muscle cells
Although lysophosphatidic acid (LPA) is known to increase intracellularfree calcium concentration ([Ca2+]i) in different cell… 
Highly Cited
2004
Highly Cited
2004
Initial structure-activity relationships of lysophosphatidic acid receptor antagonists: discovery of a high-affinity LPA1/LPA3 receptor antagonist.
Highly Cited
2003
Highly Cited
2003
Identification of a Phosphothionate Analogue of Lysophosphatidic Acid (LPA) as a Selective Agonist of the LPA3 Receptor*
Lysophosphatidic acid (LPA) is a bioactive lysophospholipid mediator that acts through G protein-coupled receptors. Most cell… 
Highly Cited
2003
Highly Cited
2003
Selective blockade of lysophosphatidic acid LPA3 receptors reduces murine renal ischemia-reperfusion injury.
Lysophosphatidic acid (LPA) released during ischemia has diverse physiological effects via its G protein-coupled receptors, LPA1… 
Highly Cited
2001
Highly Cited
2001
Activity of 2-substituted lysophosphatidic acid (LPA) analogs at LPA receptors: discovery of a LPA1/LPA3 receptor antagonist.
The physiological implications of lysophosphatidic acid occupancy of individual receptors are largely unknown because selective… 
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