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VPC 12249

Known as: VPC-12249, VPC12249 
 
National Institutes of Health

Topic mentions per year

Topic mentions per year

2001-2016
01220012016

Papers overview

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2014
2014
Lysophosphatidic acid receptor type 1 (LPA1) plays a functional role in osteoclast differentiation and bone resorption activity.
Lysophosphatidic acid (LPA) is a natural bioactive lipid that acts through six different G protein-coupled receptors (LPA1-6… (More)
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2011
2011
Blockade of lysophosphatidic acid receptors LPAR1/3 ameliorates lung fibrosis induced by irradiation.
Lung fibrosis is a common and serious complication of radiation therapy for lung cancer, for which there are no efficient… (More)
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2010
2010
Effects of lysophosphatidic acid and its receptors LPAâ…“ on radiation pneumonitis.
Radiation pneumonitis (RP) is a serious complication of radiation therapy for thoracic tumors. Lysophosphatidic acid (LPA) and… (More)
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2008
2008
Mechanisms of the lysophosphatidic acid-induced increase in [Ca2+]i in skeletal muscle cells
Although lysophosphatidic acid (LPA) is known to increase intracellularfree calcium concentration ([Ca(2+)](i)) in different cell… (More)
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Highly Cited
2004
Highly Cited
2004
Lysophosphatidic acid (LPA) in malignant ascites stimulates motility of human pancreatic cancer cells through LPA1.
Cytokines and growth factors in malignant ascites are thought to modulate a variety of cellular activities of cancer cells and… (More)
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2004
2004
Initial structure-activity relationships of lysophosphatidic acid receptor antagonists: discovery of a high-affinity LPA1/LPA3 receptor antagonist.
A recently reported dual LPA1/LPA3 receptor antagonist (VPC12249, 1) has been modified herein so as to optimize potency and… (More)
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2003
2003
Identification of a phosphothionate analogue of lysophosphatidic acid (LPA) as a selective agonist of the LPA3 receptor.
Lysophosphatidic acid (LPA) is a bioactive lysophospholipid mediator that acts through G protein-coupled receptors. Most cell… (More)
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2003
2003
Selective blockade of lysophosphatidic acid LPA3 receptors reduces murine renal ischemia-reperfusion injury.
Lysophosphatidic acid (LPA) released during ischemia has diverse physiological effects via its G protein-coupled receptors, LPA1… (More)
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2001
2001
Activity of 2-substituted lysophosphatidic acid (LPA) analogs at LPA receptors: discovery of a LPA1/LPA3 receptor antagonist.
The physiological implications of lysophosphatidic acid occupancy of individual receptors are largely unknown because selective… (More)
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2001
2001
ACCELERATED COMMUNICATION Activity of 2-Substituted Lysophosphatidic Acid (LPA) Analogs at LPA Receptors: Discovery of a LPA1/LPA3 Receptor Antagonist
The physiological implications of lysophosphatidic acid occupancy of individual receptors are largely unknown because selective… (More)
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