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MicroRNA-155 is essential for T(H)2-mediated allergen-induced eosinophilic inflammation in the lung.
- Carina Malmhäll, Sahar Alawieh, +4 authors Madeleine Rådinger
- The Journal of allergy and clinical immunology
- 2013
BACKGROUND
Allergic asthma is a chronic disease of the conducting airways characterized by T(H)2 inflammation and tissue remodeling after exposure to inhaled allergens. Although the T(H)2 profile is… (More)
- Carina Malmhäll, Apostolos Bossios, +4 authors Jan Lötvall
- PloS one
- 2012
BACKGROUND
The immune process driving eosinophilic and non-eosinophilic asthma is likely driven by different subsets of T helper (Th) cells. Recently, in vitro studies and animal studies suggest that… (More)
- Madeleine Rådinger, Apostolos Bossios, +5 authors Jan Lötvall
- Immunology
- 2011
Emerging evidence suggests that haematopoietic CD34(+) progenitor cells migrate from bone marrow (BM) to sites of allergen exposure where they can undergo further proliferation and final maturation,… (More)
- Ann-Sophie Alm, Ka Kit Li, Dong Yang, Roland Andersson, You Lu, Xiangdong Wang
- Cytokine
- 2010
OBJECTIVES
The lipopolysaccharide (LPS)-induced acute lung injury (ALI) model has been widely applied for pathophysiological and pharmacological research. The aim of present study is to understand… (More)
- You Lu, Carina Malmhäll, +4 authors Apostolos Bossios
- PloS one
- 2011
Allergic asthma is associated with airway eosinophilia, which is regulated by different T-effector cells. T cells express transcription factors T-bet, GATA-3, RORγt and Foxp3, representing Th1, Th2,… (More)
- Konstantinos Samitas, Carina Malmhäll, +8 authors Apostolos Bossios
- PloS one
- 2016
BACKGROUND
B cells, key cells in allergic inflammation, differentiate in the bone marrow and their precursors include pro-B, pre-B and immature B cells. Eosinophil progenitor cells increase in the… (More)
- Yuncong Liu, Li Wu, +6 authors You Lu
- Front. Pharmacol.
- 2019
Cervical cancer is one of the most common gynecological tumors, and the majority of early-stage cervical cancer patients achieve good recovery through surgical treatment and concurrent… (More)
- Ya-lan Wu, Rui-Zhan Tong, +12 authors You Lu
- 2017
e20625Background: T790M mutation is the most common mechanism of acquired EGFR TKI resistance. The use of T790M-targeted EGFR TKIs needs re-biopsy to confirm the existence of sensitive mutation. Pe...
- You Lu, Meijuan Huang, +20 authors Weimin Li
- 2018
Background Although successful discovery and applications of genome editing system, CRISPR/Cas9 (clustered regularly interspaced short palindromic repeats/associated nuclease 9), has been reported in… (More)
- You Lu
- 2011
Introduction: Asthma is a heterogeneous chronic lung disease associated with pronounced inflammatory changes in the airways. Eosinophilic inflammation is the trait that is best linked to symptoms and… (More)