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VHL gene

Known as: VHL, Von Hippel Lindau Tumor Supressor Gene, von Hippel-Lindau tumor suppressor 
This gene is involved in transcriptional repression and protein degradation.
National Institutes of Health

Related topics

Related topics

29 relations
Central Nervous System HemangioblastomaCerebellar hemangioblastomaFunctional Pancreatic Neuroendocrine TumorGlucagonoma

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2018
2018
In silico VHL Gene Mutation Analysis and Prognosis of Pancreatic Neuroendocrine Tumors in von Hippel–Lindau Disease
Context Patients with von Hippel-Lindau (vHL) disease caused by a missense VHL mutation have a more severe phenotype compared… 
2017
2017
Rootletin prevents Cep68 from VHL-mediated proteasomal degradation to maintain centrosome cohesion.
2017
2017
Renal Cell Carcinoma With Leiomyomatous Stroma: A Group of Tumors With Indistinguishable Histopathologic Features, But 2 Distinct Genetic Profiles Next-Generation Sequencing Analysis of 6 Cases…
We have studied a cohort of renal cell carcinomas (RCCs) with smooth-muscle stroma (N=6), which lacked any of following genetic… 
2017
2017
Centrosomal MCM7 strengthens the Cep68-VHL interaction and excessive MCM7 leads to centrosome splitting resulting from increase in Cep68 ubiquitination and proteasomal degradation.
2015
2015
Renal cell carcinoma risk is associated with the interactions of APOE, VHL and MTHFR gene polymorphisms.
OBJECTIVE The study was designed to explore the association of renal cell carcinoma (RCC) with VHL (rs779805), MTHFR (rs1801133… 
2009
2009
Regulation of DNA topoisomerase IIalpha stability by the ECV ubiquitin ligase complex.
Review
2007
Review
2007
The von hippel-lindau tumor suppressor protein: an update.
2006
2006
Molecular analysis of two uncharacterized sequence variants of the VHL gene
AbstractMutations in the VHL gene cause von Hippel-Lindau disease, a cancer predisposing syndrome characterized by a variety of… 
2001
2001
DHPLC-based germline mutation screening in the analysis of the VHL tumor suppressor gene: usefulness and limitations
Abstract. In order to evaluate the sensitivity and specificity of the recently introduced high-throughput method DHPLC… 
2000
2000
Inactivation of the human fragile histidine triad gene at 3p14.2 in monochromosomal human/mouse microcell hybrid-derived severe combined immunodeficient mouse tumors.
We have previously shown that inoculation of human chromosome 3 (chr3)/A9 mouse fibrosarcoma microcell hybrids (MCHs) into severe… 
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