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VHL gene

Known as: VHL, Von Hippel Lindau Tumor Supressor Gene, von Hippel-Lindau tumor suppressor 
This gene is involved in transcriptional repression and protein degradation.
National Institutes of Health

Papers overview

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Highly Cited
2019
Highly Cited
2019
PROteolysis-TArgeting Chimeras (PROTACs) are hetero-bifunctional molecules that recruit an E3 ubiquitin ligase to a given… Expand
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Highly Cited
2015
Highly Cited
2015
Foxp3(+) regulatory T (Treg) cells play a critical role in immune homeostasis; however, the mechanisms to maintain their function… Expand
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Highly Cited
2014
Highly Cited
2014
VHL is mutated in the majority of patients with clear cell renal cell carcinoma (ccRCC), with conflicting clinical relevance… Expand
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Highly Cited
2006
Highly Cited
2006
The ring-shaped hetero-oligomeric chaperonin TRiC/CCT uses ATP to fold a diverse subset of eukaryotic proteins. To define the… Expand
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Highly Cited
2005
Highly Cited
2005
The mechanisms by which molecular chaperones assist quality control of cytosolic proteins are poorly understood. Analysis of the… Expand
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Highly Cited
2004
Highly Cited
2004
The ECS (Elongin B/C-Cul2/Cul5-SOCS-box protein) complex is a member of a family of ubiquitin ligases that share a Cullin-Rbx… Expand
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Highly Cited
2001
Highly Cited
2001
The von Hippel-Lindau tumour suppressor gene product (pVHL) associates with the elongin B and C and Cul2 proteins to form a… Expand
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Highly Cited
2000
Highly Cited
2000
To elucidate the role of somatic alterations for renal cancer etiology and prognosis, we analyzed 227 sporadic renal epithelial… Expand
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Highly Cited
1997
Highly Cited
1997
The von Hippel-Lindau tumor suppressor gene (VHL) has a critical role in the pathogenesis of clear-cell renal cell carcinoma (RCC… Expand
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Highly Cited
1997
Highly Cited
1997
Inherited predisposition to phaeochromocytoma (MIM No 171300) occurs in multiple endocrine neoplasia type 2 (MEN 2) (MIM No… Expand
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