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Horizontal transfer of oncogenes by uptake of apoptotic bodies
Evidence is provided that tumor DNA may be horizontally transferred by the uptake of apoptotic bodies and that lateral transfer of DNA between eukaryotic cells may result in aneuploidy and the accumulation of genetic changes that are necessary for tumor formation.
Horizontal transfer of DNA by the uptake of apoptotic bodies.
The findings suggest that apoptotic bodies derived from EBV-carrying B lymphocytes may serve as the source of viral transfer to cells that lack receptors for the EBV virus in vivo.
Restricted expression of Epstein-Barr virus (EBV)-encoded, growth transformation-associated antigens in an EBV- and human herpesvirus type 8-carrying body cavity lymphoma line.
A body cavity lymphoma-derived cell line (BC1), known to carry both Epstein-Barr virus (EBV) and human herpes virus type 8 (HHV-8; or Kaposi's sarcoma-associated herpesvirus, KSHV), was analysed for
Epstein–Barr virus promotes genomic instability in Burkitt's lymphoma
It is reported that EBV carriage promotes genomic instability in Burkitt's lymphoma (BL) and induction of telomere dysfunction and DNA damage as important mechanisms for EBV oncogenesis.
De novo chromosome formations by large-scale amplification of the centromeric region of mouse chromosomes
The results indicate that the building units of the pericentric heterochromatin of mouse chromosomes are ∼7.5-Mb blocks of satellite DNA flanked by nonsatellite sequences, suggesting that the formationde novo of various chromosome segments and chromosomes seen in different cell lines may be the result of large-scale E- and H-type amplification initiated in the perICentric region of chromosomes.
Loss of the p21(Cip1/Waf1) cyclin kinase inhibitor results in propagation of horizontally transferred DNA.
The data indicate that p53, via the activation of p21, blocks normal cells from replicating transferred DNA from engulfed apoptotic bodies, which may be one protection level against the propagation of potentially pathological DNA.
Visualization of Alternative Epstein-Barr Virus Expression Programs by Fluorescent In Situ Hybridization at the Cell Level
A “track” signal is obtained with aBamHI W DNA probe that could hybridize with the polycistronic but not with the monocistronic message in two type III BL lines and three LCLs and a positive signal was obtained with the Bam HI K but not the BamHI W probe in the type I BL lines MUTU I and Rael.
A 3p21.3 region is preferentially eliminated from human chromosome 3/mouse microcell hybrids during tumor growth in SCID mice
This finding is consistent with the notion that a tumor suppressor gene may be located in this area, as suggested by frequent loss of heterozygosity (LOH) within this region observed in several types of solid tumors.
Centromere formation in mouse cells cotransformed with human DNA and a dominant marker gene.
In situ hybridization demonstrated that the human DNA sequence as well as the APH-II gene and vector DNA sequences were located only in the additional centromere of the dicentric chromosome.
Human/mouse microcell hybrid based elimination test reduces the putative tumor suppressor region at 3p21.3 to 1.6 cM
The results of the more detailed analysis on 24 SCID mouse tumors derived from two MCH lines that originally carried intact human chromosomes 3.2 and 3.3 are reported, finding a common eliminated region of approximately 1.6 cM inside the 7 cM CER described earlier.