VHH Immunoglobulin Fragments

Known as: VHH Fragments, Immunoglobulin Fragments, VHH, Fragments, VHH 
An immunoglobulin fragment composed of one variable domain from an IMMUNOGLOBULIN HEAVY CHAIN from the serum of camelids (ALPACAS, LLAMAS, CAMELS… (More)
National Institutes of Health

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Broader (1)

Single-Domain Antibodies

Papers overview

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Review
2017
Review
2017
Exosomes: Therapy delivery tools and biomarkers of diseases.
Virtually all cells in the organism secrete extracellular vesicles (EVs), a heterogeneous population of lipid bilayer membrane… (More)
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Review
2013
Review
2013
Nanobodies: natural single-domain antibodies.
Sera of camelids contain both conventional heterotetrameric antibodies and unique functional heavy (H)-chain antibodies (HCAbs… (More)
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Highly Cited
2012
Highly Cited
2012
A simple, versatile method for GFP-based super-resolution microscopy via nanobodies
We developed a method to use any GFP-tagged construct in single-molecule super-resolution microscopy. By targeting GFP with small… (More)
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2012
2012
Aptamers as potential tools for super-resolution microscopy
aptamer size can be modulated trivially by coupling additional nucleotides to the original structure. Using the PSMA aptamer, we… (More)
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Review
2011
Review
2011
Nanobody stabilization of G protein-coupled receptor conformational states.
Remarkable progress has been made in the field of G protein-coupled receptor (GPCR) structural biology during the past four years… (More)
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Highly Cited
2011
Highly Cited
2011
A biparatopic anti-EGFR nanobody efficiently inhibits solid tumour growth.
The epidermal growth factor receptor (EGFR) has been shown to be a valid cancer target for antibody-based therapy. At present… (More)
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2011
2011
Localization, mechanism and reduction of renal retention of technetium-99m labeled epidermal growth factor receptor-specific nanobody in mice.
BACKGROUND Nanobodies are single-domain antigen binding fragments derived from functional heavy-chain antibodies elicited in… (More)
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Review
2011
Review
2011
Nanobodies®: new ammunition to battle viruses.
In 1989, a new type of antibody was identified, first in the sera of dromedaries and later also in all other species of the… (More)
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Highly Cited
2010
Highly Cited
2010
CXCR4 nanobodies (VHH-based single variable domains) potently inhibit chemotaxis and HIV-1 replication and mobilize stem cells.
The important family of G protein-coupled receptors has so far not been targeted very successfully with conventional monoclonal… (More)
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Highly Cited
2006
Highly Cited
2006
Targeting and tracing antigens in live cells with fluorescent nanobodies
We fused the epitope-recognizing fragment of heavy-chain antibodies from Camelidae sp. with fluorescent proteins to generate… (More)
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