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VEGF/HGF-targeting DARPin MP0250

Known as: Bispecific VEGF/HGF-targeting Darpin, MP0250 
A designed ankyrin repeat proteins (DARPin)-based agent targeting vascular endothelial growth factor (VEGF) and hepatocyte growth factor (HGF), with… 
National Institutes of Health

Related topics

Related topics

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NCIt Antineoplastic Agent Terminology

Papers overview

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2018
2018
First-in-class phase I study evaluating MP0250, a VEGF and HGF neutralizing DARPIN molecule, in patients with advanced solid tumors.
2520Background: The VEGF/VEGFR and HGF/c-MET pathways are key mediators of the growth of solid tumours. MP0250 is a first-in… 
2016
2016
Preliminary biomarker and pharmacokinetic analysis from the completed dose escalation part of the first-in-human Phase I study evaluating MP0250, a multi-DARPin® blocking HGF and VEGF-A, in patients…
2016
2016
Anti-HER2 phototoxin based on flavoprotein miniSOG causes the oxidative stress and necrosis of HER2-positive cancer cells
Development and functional characterization of novel, high-affinity protein compounds able to selectively kill human cancer cells… 
2015
2015
Abstract B25: First-in-human Phase I study to evaluate MP0250, a DARPin blocking HGF and VEGF, in patients with advanced solid tumors
Background: The VEGF/VEGFR and HGF/cMet pathways are implicated in tumor survival, growth, angiogenesis, invasion and metastasis… 
2015
2015
Internalization and Recycling of the HER2 Receptor on Human Breast Adenocarcinoma Cells Treated with Targeted Phototoxic Protein DARPinminiSOG
Design and evaluation of new high-affinity protein compounds that can selectively and efficiently destroy human cancer cells are… 
2014
2014
Antitumor activity of MP0250, a bispecific VEGF- and HGF-targeting darpin, in patient-derived xenograft models.
11039 Background: The interplay of tumor cells and their microenvironment is crucial in the growth of solid tumors. Key mediators… 
2011
2011
Designed ankyrin repeat protein binders for the crystallization of AcrB: plasticity of the dominant interface.
2011
2011
215 In Vivo Binding and Retention of CD4-Specific DARPin 57.2 in Macaques
2010
2010
In Vivo Binding and Retention of CD4-Specific DARPin 57.2 in Macaques
Background The recently described Designed Ankyrin Repeat Protein (DARPin) technology can produce highly selective ligands to a… 
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