V158411

 
National Institutes of Health

Topic mentions per year

Topic mentions per year

2014-2018
02420142018

Papers overview

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2018
2018
Understanding drug target engagement and the relationship to downstream pharmacology is critical for drug discovery. Here we have… (More)
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2016
2016
Chk1 kinase is a critical component of the DNA damage response checkpoint and Chk1 inhibitors are currently under clinical… (More)
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2016
2016
BACKGROUND Chk1 inhibitors are currently under clinical evaluation as single agents and in combination with cytotoxic… (More)
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2016
2016
Radiation-induced DNA damage activates the DNA damage response (DDR). DDR up-regulation may predict radio-resistance and increase… (More)
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2016
2016
The Chk1 and ATR kinases are critical mediators of the DNA damage response pathway and help protect cancer cells from endogenous… (More)
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2015
2015
Chk1 kinase is a critical component of the DNA damage response checkpoint especially in cancer cells and targeting Chk1 is a… (More)
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2014
2014
Chk1 forms a core component of the DNA damage response and small molecule inhibitors are currently being investigated in the… (More)
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2014
2014
Chk1 inhibitors are currently in clinical trials as putative potentiators of cytotoxic chemotherapy drugs. Chk1 inhibitors may… (More)
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2014
2014
Chk1 inhibitors are currently in clinical trials in combination with a range of cytotoxic agents and have the potential to… (More)
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