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Uncoupling Protein 3

Known as: SLC25A9 Protein, Mitochondrial Uncoupling Protein 3, Solute Carrier Family 25 Member 9 
A mitochondrial uncoupling protein that is expressed in heart and skeletal muscle tissues. It functions to regulate tissue respiration, energy… 
National Institutes of Health

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Papers overview

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Highly Cited
2011
Highly Cited
2011
A high fat diet increases mitochondrial fatty acid oxidation and uncoupling to decrease efficiency in rat heart
Elevated levels of cardiac mitochondrial uncoupling protein 3 (UCP3) and decreased cardiac efficiency (hydraulic power/oxygen… 
Review
2010
Review
2010
Mitochondrial dysfunction and lipotoxicity.
Highly Cited
2007
Highly Cited
2007
Overexpression of uncoupling protein 3 in skeletal muscle protects against fat-induced insulin resistance.
Insulin resistance is a major factor in the pathogenesis of type 2 diabetes and is strongly associated with obesity. Increased… 
Highly Cited
2003
Highly Cited
2003
Pharmacology: Uncoupling the agony from ecstasy
The recreational use of amphetamine-type stimulants can produce a marked and sometimes lethal increase in body temperature. Here… 
Highly Cited
2001
Highly Cited
2001
In Vivo Effects of Uncoupling Protein-3 Gene Disruption on Mitochondrial Energy Metabolism*
To clarify the role of uncoupling protein-3 (UCP3) in skeletal muscle, we used NMR and isotopic labeling experiments to evaluate… 
Highly Cited
2001
Highly Cited
2001
Uncoupling protein 3 content is decreased in skeletal muscle of patients with type 2 diabetes.
Recently, a role for uncoupling protein-3 (UCP3) in carbohydrate metabolism and in type 2 diabetes has been suggested. Mice… 
Highly Cited
2001
Highly Cited
2001
Aging skeletal muscle mitochondria in the rat: decreased uncoupling protein-3 content.
The goal of the present study was to discern the cellular mechanism(s) that contributes to the age-associated decrease in… 
Highly Cited
2000
Highly Cited
2000
Mice overexpressing human uncoupling protein-3 in skeletal muscle are hyperphagic and lean
Uncoupling protein-3 (UCP-3) is a recently identified member of the mitochondrial transporter superfamily that is expressed… 
Highly Cited
1999
Highly Cited
1999
Activators of peroxisome proliferator-activated receptor-alpha induce the expression of the uncoupling protein-3 gene in skeletal muscle: a potential mechanism for the lipid intake-dependent…
The recently identified uncoupling protein-3 (UCP-3) gene, predicted to encode a new member of the family of uncoupling proteins… 
Highly Cited
1997
Highly Cited
1997
The Human Uncoupling Protein-3 Gene
Uncoupling protein-3 (UCP3) is a recently identified candidate mediator of adaptive thermogenesis in humans. Unlike UCP1 and UCP2… 
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