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Guidelines for the use and interpretation of assays for monitoring autophagy
These guidelines are presented for the selection and interpretation of methods for use by investigators who aim to examine macroautophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.
Oxidants, oxidative stress and the biology of ageing
Evidence that the appropriate and inappropriate production of oxidants, together with the ability of organisms to respond to oxidative stress, is intricately connected to ageing and life span is reviewed.
Mitochondria, Oxidants, and Aging
Circulating endothelial progenitor cells, vascular function, and cardiovascular risk.
- Jonathan M. Hill, G. Zalos, T. Finkel
- Biology, MedicineThe New England journal of medicine
- 1 July 2003
In healthy men, levels of endothelial progenitor cells may be a surrogate biologic marker for vascular function and cumulative cardiovascular risk and suggest that endothelial injury in the absence of sufficient circulating progenitors may affect the progression of cardiovascular disease.
Requirement for Generation of H2O2 for Platelet-Derived Growth Factor Signal Transduction
The results suggest that H2O2 may act as a signal-transducing molecule, and they suggest a potential mechanism for the cardioprotective effects of antioxidants.
53BP1 Inhibits Homologous Recombination in Brca1-Deficient Cells by Blocking Resection of DNA Breaks
A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy
The results suggest that the Sirt1 deacetylase is an important in vivo regulator of autophagy and provide a link between sirtuin function and the overall cellular response to limited nutrients.
A role for the mitochondrial deacetylase Sirt3 in regulating energy homeostasis
- B. Ahn, Hyun-Seok Kim, T. Finkel
- BiologyProceedings of the National Academy of Sciences
- 23 September 2008
It is shown that Sirt3 functions in vivo to regulate and maintain basal ATP levels and as a regulator of mitochondrial electron transport and implicate protein acetylation as an important regulator of Complex I activity.
Signal transduction by reactive oxygen species
- T. Finkel
- BiologyThe Journal of cell biology
- 11 July 2011
Emerging evidence suggests that ROS regulate diverse physiological parameters ranging from the response to growth factor stimulation to the generation of the inflammatory response, and that dysregulated ROS signaling may contribute to a host of human diseases.
SIRT1 Functionally Interacts with the Metabolic Regulator and Transcriptional Coactivator PGC-1α*
The cellular effects of overexpression of SIRT1, the closest mammalian ortholog of Sir2, are examined and it is demonstrated that SIRT 1 catalyzes PGC-1α deacetylation both in vitro and in vivo.