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Guidelines for the use and interpretation of assays for monitoring autophagy
In 2008 we published the first set of guidelines for standardizing research in autophagy. Since then, research on this topic has continued to accelerate, and many new scientists have entered theExpand
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Oxidants, oxidative stress and the biology of ageing
Living in an oxygenated environment has required the evolution of effective cellular strategies to detect and detoxify metabolites of molecular oxygen known as reactive oxygen species. Here we reviewExpand
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Circulating endothelial progenitor cells, vascular function, and cardiovascular risk.
BACKGROUND Cardiovascular risk factors contribute to atherogenesis by inducing endothelial-cell injury and dysfunction. We hypothesized that endothelial progenitor cells derived from bone marrow haveExpand
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Mitochondria, Oxidants, and Aging
The free radical theory of aging postulates that the production of intracellular reactive oxygen species is the major determinant of life span. Numerous cell culture, invertebrate, and mammalianExpand
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Requirement for Generation of H2O2 for Platelet-Derived Growth Factor Signal Transduction
Stimulation of rat vascular smooth muscle cells (VSMCs) by platelet-derived growth factor (PDGF) transiently increased the intracellular concentration of hydrogen peroxide (H2O2). This increase couldExpand
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53BP1 Inhibits Homologous Recombination in Brca1-Deficient Cells by Blocking Resection of DNA Breaks
Defective DNA repair by homologous recombination (HR) is thought to be a major contributor to tumorigenesis in individuals carrying Brca1 mutations. Here, we show that DNA breaks in Brca1-deficientExpand
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A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy
We demonstrate a role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy. In particular, transient increased expression of Sirt1 is sufficient to stimulate basal rates ofExpand
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A role for the mitochondrial deacetylase Sirt3 in regulating energy homeostasis
Here, we demonstrate a role for the mitochondrial NAD-dependent deacetylase Sirt3 in the maintenance of basal ATP levels and as a regulator of mitochondrial electron transport. We note that Sirt3−/−Expand
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SIRT1 Functionally Interacts with the Metabolic Regulator and Transcriptional Coactivator PGC-1α*
In lower organisms, increased expression of the NAD-dependent deacetylase Sir2 augments lifespan. The mechanism through which this life extension is mediated remains incompletely understood. Here weExpand
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Signal transduction by reactive oxygen species
  • T. Finkel
  • Biology, Medicine
  • The Journal of cell biology
  • 11 July 2011
Although historically viewed as purely harmful, recent evidence suggests that reactive oxygen species (ROS) function as important physiological regulators of intracellular signaling pathways. TheExpand
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