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Gut-selective blockade of lymphocyte trafficking by vedolizumab may constitute effective treatment for ulcerative… Expand Crohn's disease and ulcerative colitis are idiopathic, chronic, relapsing, inflammatory conditions that are immunologically… Expand BACKGROUND
Infliximab, a chimeric monoclonal antibody directed against tumor necrosis factor alpha, is an established treatment… Expand BACKGROUND AND AIMS Controversy surrounds the risk of colorectal cancer (CRC) in ulcerative colitis (UC). Many studies have… Expand BACKGROUND
There has been no new effective drug therapy for patients with severe ulcerative colitis since corticosteroids were… Expand Mice deficient for interleukin-2 develop normally during the first 3-4 weeks of age. However, later on they become severely… Expand BACKGROUND
The risk of colorectal cancer is increased among patients with ulcerative colitis. The magnitude of this increase in… Expand We assessed oral 5-aminosalicylic acid (5-ASA) prepared with a pH-sensitive polymer coating in 87 patients with mildly to… Expand developing countries. It has been proposed that this is the result of improved hygiene and sanitation, which have led to reduced… Expand