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Ubiquitin-Activating Enzymes

Known as: Ubiquitin Activating Enzyme, Enzyme, Ubiquitin-Activating, Ubiquitin-Activating Enzymes [Chemical/Ingredient] 
A class of enzymes that catalyzes the ATP-dependent formation of a thioester bond between itself and UBIQUITIN. It then transfers the activated… Expand
National Institutes of Health

Papers overview

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Highly Cited
2018
Highly Cited
2018
The ubiquitin–proteasome system (UPS) comprises a network of enzymes that is responsible for maintaining cellular protein… Expand
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Highly Cited
2007
Highly Cited
2007
UBE1 is known as the human ubiquitin-activating enzyme (E1), which activates ubiquitin in an ATP-dependent manner. Here, we… Expand
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2005
2005
Protein ubiquitination requires the sequential activity of three enzymes: a ubiquitin-activating enzyme (E1), a ubiquitin… Expand
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Highly Cited
2001
Highly Cited
2001
BackgroundThe eukaryotic ubiquitin-conjugation system sets the turnover rate of many proteins and includes activating enzymes… Expand
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Highly Cited
2000
Highly Cited
2000
ABSTRACT In normal cells, p53 is maintained at a low level by ubiquitin-mediated proteolysis, but after genotoxic insult this… Expand
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Highly Cited
1997
Highly Cited
1997
Ubiquitin conjugating enzymes participate in the thioester cascade that leads to protein ubiquitination. Although Ubc9 is… Expand
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Review
1997
Review
1997
The covalent attachment of the polypeptide ubiquitin to proteins marks them for degradation by the ubiquitin/26S proteasome… Expand
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Highly Cited
1995
Highly Cited
1995
Little is known regarding the mechanism by which MHC class I-associated peptides are generated. Proteins can be targeted for… Expand
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Highly Cited
1991
Highly Cited
1991
All known functions of ubiquitin are mediated through its covalent attachment to other proteins. The post‐translational formation… Expand
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Highly Cited
1982
Highly Cited
1982
 
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