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Ubiquitin-Activating Enzymes

Known as: Ubiquitin Activating Enzyme, Enzyme, Ubiquitin-Activating, Ubiquitin-Activating Enzymes [Chemical/Ingredient] 
A class of enzymes that catalyzes the ATP-dependent formation of a thioester bond between itself and UBIQUITIN. It then transfers the activated… 
National Institutes of Health

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CsdL protein, E coliUBA2 protein, humanUBA3 protein, human
In BloodProcess of secretionantagonists & inhibitorsaspects of radiation effects

Papers overview

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2019
2019
Abstract 2699: Targeting an ubiquitin-activating enzyme in small-cell lung cancer (SCLC)
Background: Despite valiant efforts to improve patient outcomes, small cell lung cancer (SCLC) (~15-17% of lung cancer) remains… 
2014
2014
Characterization of Ubiquitin-Activating Enzyme Uba1 in the Nucleus by Its Mammalian Temperature-Sensitive Mutant
Temperature-sensitive (ts) CHO-K1 mutant tsTM3 exhibits chromosomal instability and cell-cycle arrest in the S to G2 phases with… 
Review
2013
Review
2013
Minireview: ubiquitination-regulated G protein-coupled receptor signaling and trafficking.
G protein-coupled receptors (GPCRs) are the largest and most diverse superfamily of membrane proteins and mediate most cellular… 
2008
2008
Synthesis of bisphosphonate derivatives of ATP by T4 DNA ligase, ubiquitin activating enzyme (E1) and other ligases.
2007
2007
Targeting proteasome worsens atherosclerosis.
See related article, pages 865–874 The ubiquitin–proteasome system is the major pathway (up to 80% to 90%) of nonlysosomal… 
2002
2002
Apoptosis in Schwann Cell Cultures Is Closely Interrelated with the Activity of the Ubiquitin-Proteasome Proteolytic Pathway
Although the participation of the ubiquitin-dependent pathway and of the proteasome in apoptosis has been proposed, its role in… 
2000
2000
Molecular characterization of the thermosensitive E1 ubiquitin-activating enzyme cell mutant A31N-ts20. Requirements upon different levels of E1 for the ubiquitination/degradation of the various…
According to our current knowledge, protein ubiquitination involves three steps: activation of ubiquitin through formation of an… 
1998
1998
The ubiquityl-calmodulin synthetase system from rabbit reticulocytes: isolation of the ubiquitin-binding first component, a ubiquitin-activating enzyme.
Ubiquitin is often implicated as a specific tag for protein degradation via the ubiquitin system although only a limited number… 
1990
1990
Ubiquitin metabolism in ts85 cells, a mouse carcinoma line that contains a thermolabile ubiquitin activating enzyme.
1987
1987
A specific endpoint assay for ubiquitin.
Simple endpoint assays for free ubiquitin (Ub) and for the Ub-activating enzyme are described. The method for measuring Ub makes… 
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