Ubiquilin-2

Known as: hPLIC-2, Chap1, NEDD4 Binding Protein 4 
Ubiquilin-2 (624 aa, ~66 kDa) is encoded by the human UBQLN2 gene. This protein may play a role in the modulation of proteasome-mediated protein… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

2000-2017
012320002017

Papers overview

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2016
2016
Mutations in Ubiquilin-2 are linked to the onset of amyotrophic lateral sclerosis, but its connection to disease processes has… (More)
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2015
2015
UBQLN2 mutations have recently been associated with familial forms of amyotrophic lateral sclerosis (ALS) and ALS-dementia… (More)
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2015
2015
Ubiquilin proteins facilitate delivery of ubiquitinated proteins to the proteasome for degradation. Interest in the proteins has… (More)
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2015
2015
Mutations in the gene encoding Ubiquilin-2 (UBQLN2) are linked to amyotrophic lateral sclerosis (ALS) and frontotemporal dementia… (More)
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2013
2013
OBJECTIVES Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease mainly involving cortical and spinal motor neurones… (More)
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2013
2013
Recently, it was reported that mutations in the ubiquitin-like protein ubiquilin-2 (UBQLN2) are associated with X-linked… (More)
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2003
2003
The ubiquitin-like hPLIC proteins can associate with proteasomes, and hPLIC overexpression can specifically interfere with… (More)
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Highly Cited
2002
Highly Cited
2002
The 26S proteasome is essential for the proteolysis of proteins that have been covalently modified by the attachment of… (More)
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Highly Cited
2000
Highly Cited
2000
Although there is a binding site on the proteasome for the polyubiquitin chains attached to degradation substrates by the… (More)
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2000
2000
We have isolated two human ubiquitin-like (UbL) proteins that bind to a short peptide within the ATPase domain of the Hsp70-like… (More)
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