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USP28 gene

Known as: USP28, UBIQUITIN-SPECIFIC PROTEASE 28, Ubiquitin Specific Peptidase 28 Gene 
This gene plays a role in both protein deubiquitination and DNA damage responses.
National Institutes of Health

Related topics

Related topics

6 relations
Cell Cycle CheckpointsCell ProliferationDeubiquitinationHydrolysis

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2020
2020
Deubiquitinase USP28 inhibits ubiquitin ligase KLHL2-mediated uridine-cytidine kinase 1 degradation and confers sensitivity to 5'-azacytidine-resistant human leukemia cells
Resistance to the chemotherapeutic drug 5'-azacytidine (5'-AZA) is a major obstacle in the treatment of patients with acute… 
2020
2020
Computational approach to target USP28 for regulating Myc
2020
2020
Late effects of cutaneous 3-methylcholanthrene exposure on DNA damage-related pleiotropic growth factors and oxidative stress markers in mice.
BACKGROUND Skin is the body's first defence against direct exposure to variety of chemicals. Polycyclic aromatic hydrocarbons… 
2016
2016
BRAF inhibitor resistance enhances vulnerability to arginine deprivation in melanoma
BRAF inhibitor (BRAFi) has been used for treatment of melanomas harboring V600E mutation. Despite a high initial response rate… 
2015
2015
The N-terminal ubiquitin-binding region of ubiquitin-specific protease 28 modulates its deubiquitination function: NMR structural and mechanistic insights.
The deubiquitinase ubiquitin-specific protease 28 (Usp28) contains a ubiquitin-binding region (UBR) composed of one ubiquitin… 
Review
2014
Review
2014
Toxicogenomic effect of nickel and beyond
Nickel is widely applied in industrial settings and Ni(II) compounds have been classified as group one human carcinogens. The… 
2014
2014
Structural and functional studies on the regulation of the USP28 de-ubiquitinase and the SENP5 de-SUMOylase
USP28 es un enzim de-ubiquitinasa (DUBs), homologa a USP25, que pertany a la familia USPs. USP28 s’ha involucrat en apoptosis… 
2013
2013
Reactive Oxygen Species-Dependent Down-Regulation of Tumor Suppressor Genes PTEN, USP28, DRAM, TIGAR, and CYLD Under Oxidative Stress
We examined whether steady-state mRNA levels of five tumor suppressor genes are subjected to oxidative stress. Superoxide radical… 
2013
2013
The Deubiquitinase USP 28 Stabilizes LSD 1 and Confers Stem-Cell-like Traits to Breast Cancer Cells
Yadi Wu,1,5,* Yifan Wang,2,5 Xiuwei H. Yang,1,5 Tiebang Kang,6 Yongxiang Zhao,7 Chi Wang,3,5 B. Mark Evers,2,4,5 and Binhua P… 
2012
2012
NMR solution structure of the N-terminal domain of human USP28. Northeast structural genomics consortium target HT8470A
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