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USP25 gene

Known as: USP21, UBIQUITIN-SPECIFIC PROTEASE 25, UBIQUITIN-SPECIFIC PROTEASE ON CHROMOSOME 21 
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
Distinct USP25 and USP28 Oligomerization States Regulate Deubiquitinating Activity
2019
2019
Differential Oligomerization of the Deubiquitinases USP25 and USP28 Regulates Their Activities.
2018
2018
A quaternary tetramer assembly inhibits the deubiquitinating activity of USP25
USP25 deubiquitinating enzyme is a key member of the ubiquitin system, which acts as a positive regulator of the Wnt/β-catenin… 
Highly Cited
2017
Highly Cited
2017
Identification and Characterization of Dual Inhibitors of the USP25/28 Deubiquitinating Enzyme Subfamily.
The ubiquitin proteasome system is widely postulated to be a new and important field of drug discovery for the future, with the… 
Highly Cited
2015
Highly Cited
2015
Acute ER stress regulates amyloid precursor protein processing through ubiquitin-dependent degradation
Beta-amyloid (Aβ), a major pathological hallmark of Alzheimer's disease (AD), is derived from amyloid precursor protein (APP… 
2015
2015
Vaccinia-Related Kinase 2 Controls the Stability of the Eukaryotic Chaperonin TRiC/CCT by Inhibiting the Deubiquitinating Enzyme USP25
ABSTRACT Molecular chaperones monitor the proper folding of misfolded proteins and function as the first line of defense against… 
Highly Cited
2012
Highly Cited
2012
Negative regulation of IL-17-mediated signaling and inflammation by ubiquitin-specific protease 25
Interleukin 17 (IL-17) is important in infection and autoimmunity; how it signals remains poorly understood. In this study, we… 
Highly Cited
2009
Highly Cited
2009
The UBA-UIM Domains of the USP25 Regulate the Enzyme Ubiquitination State and Modulate Substrate Recognition
USP25m is the muscle isoform of the deubiquitinating (DUB) enzyme USP25. Similarly to most DUBs, data on USP25 regulation and… 
Highly Cited
2001
Highly Cited
2001
Characterization of alternatively spliced products and tissue-specific isoforms of USP28 and USP25
BackgroundThe ubiquitin-dependent protein degradation pathway is essential for the proteolysis of intracellular proteins and… 
1999
1999
USP25, a novel gene encoding a deubiquitinating enzyme, is located in the gene-poor region 21q11.2.
We have identified a new gene, USP25, spanning over 150 kb at 21q11. 2, one of the lowest gene-density regions of the human… 
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