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Eudragit RS100 nanosuspensions for the ophthalmic controlled delivery of ibuprofen.
TLDR
In vivo efficacy was assessed on the rabbit eye after induction of an ocular trauma (paracentesis), and an inhibition of the miotic response to the surgical trauma was achieved, comparable to a control aqueous eye-drop formulation, even though a lower concentration of free drug in the conjunctival sac was reached from the nanoparticle system. Expand
PLA/PLGA nanoparticles for sustained release of docetaxel.
TLDR
Kinetic experiments demonstrated that the release process of DTX form nanospheres is affected by the molecular weight of the employed polymers, and suggested that DTX was molecularly dispersed in the polymeric matrices. Expand
Flurbiprofen-loaded acrylate polymer nanosuspensions for ophthalmic application.
TLDR
In vivo anti-inflammatory efficacy was assessed in the rabbit eye after induction of an ocular trauma and an inhibition of the miotic response to the surgical trauma comparable to a control eye-drop formulation was obtained, even though an actual lower concentration of free drug in the conjunctival sac was achieved from the nanoparticles. Expand
Lecithin microemulsions for the topical administration of ketoprofen: percutaneous adsorption through human skin and in vivo human skin tolerability.
TLDR
The potential application of highly biocompatible o/w microemulsions as topical drug carrier systems for the percutaneous delivery of anti-inflammatory drugs, i.e. ketoprofen-loaded microemulsion formulations showed an enhanced permeation through human skin with respect to conventional formulations and a good human skin tolerability. Expand
Preparation of celecoxib-dimethyl-beta-cyclodextrin inclusion complex: characterization and in vitro permeation study.
TLDR
Water solubility and dissolution rate of CCB, in a medium simulating gastric fluid, significantly increased after complexation, with complete dissolution obtained after 30 and 180 min for the freeze-dried and kneaded complexes respectively. Expand
Liposomes as In‐vivo Carriers for Citicoline: Effects on Rat Cerebral Post‐ischaemic Reperfusion #
TLDR
The possibility of efficiently trapping citicoline in liposomes to improve its therapeutic effects is reported and a citic Caroline‐loaded phospholipid mixture has produced an increase in rat survival rate and a reduction in diene levels of 60%, compared to the free drug. Expand
Combining molecular modeling with experimental methodologies: mechanism of membrane permeation and accumulation of ofloxacin.
TLDR
In vitro experiments show that a suitable balance of hydrophilic and hydrophobic fluoroquinolone properties needs to occur for there to be increased drug permeation, and demonstrate that a pH gradient through model membranes may be responsible for a poorly homogeneous distribution of ofloxacin. Expand
Ocular tolerability of Eudragit RS100 and RL100 nanosuspensions as carriers for ophthalmic controlled drug delivery.
TLDR
Polymer nanoparticles appeared to be avoiding of any irritant effect on cornea, iris, and conjunctiva up to 24 h after application, thus appearing to be a suitable inert carrier for ophthalmic drug delivery. Expand
In vitro evaluation of idebenone-loaded solid lipid nanoparticles for drug delivery to the brain
TLDR
The tested SLN could be regarded as interesting carriers to overcome the blood brain barrier and increase the efficacy of the loaded drug. Expand
Influence of Preparation Conditions on Acyclovir-Loaded Poly-d,l-Lactic Acid Nanospheres and Effect of PEG Coating on Ocular Drug Bioavailability
TLDR
PEG-coated PLA nanospheres can be proposed as a potential ophthalmic delivery system for the treatment of ocular viral infections. Expand
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