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Abstractβ-catenin is a major transcriptional activator of the canonical Wnt/β-catenin signaling pathway. It is important for a… Expand STING (also known as MITA) mediates the innate antiviral signaling and ubiquitination of STING is key to its function. However… Expand Toll-like receptor 4 (TLR4) promotes vascular inflammatory disorders such as neointimal hyperplasia and atherosclerosis. TLR4… Expand Background: The mechanisms for recruiting and activating deubiquitinase(s) during GPCR trafficking are unknown. Results: PKA… Expand CLASPIN is an essential mediator in the DNA replication checkpoint, responsible for ATR (ataxia telangiectasia and Rad3-related… Expand The DNA damage response triggers cell-cycle checkpoints, DNA repair and apoptosis using multiple post-translational modifications… Expand Background: Rad17 is a key DNA damage response protein that undergoes ubiquitylation-mediated degradation. Results: USP20 is a… Expand Hypoxia‐inducible factor (HIF)‐1α is a short‐lived protein and is ubiquitinated and degraded through the von Hippel–Lindau… Expand The type 2 iodothyronine deiodinase (D2) is an integral membrane ER-resident selenoenzyme that activates the pro-hormone… Expand The VHL protein (pVHL) is a component of an E3 ubiquitin ligase complex which is involved in the ubiquitination and degradation… Expand