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USP1 gene

Known as: UBIQUITIN-SPECIFIC PROTEASE 1, USP1, ubiquitin specific peptidase 1 
National Institutes of Health

Papers overview

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2018
2018
Abstract 333: USP1 is required for replication fork stability in BRCA1-deficient tumors
Homologous-recombination (HR) deficient tumors with BRCA1 and BRCA2 mutations exhibit replication fork stability defects. To date… 
2017
2017
Identification of deubiquitinase targets of isothiocyanates using SILAC-assisted quantitative mass spectrometry
Cruciferous vegetables such as broccoli and kale have well documented chemopreventative and anticancer effects that are… 
2016
2016
Title: PDGF Engages an E2F-USP1 Signaling Pathway to Support ID2-mediated Survival of Proneural Glioma Cells Running title: A PDGF-E2F-USP1-ID2 axis is required for proneural glioma
2016
2016
Glioblastoma (GBM) carries a dismal prognosis with a median survival of only a little over a year (1). Current standard of care for patients includes maximal surgical resection followed by radiation…
Transl Cancer Res 2016;5(Suppl 4):S920-S922 tcr.amegroups.com Glioblastoma (GBM) carries a dismal prognosis with a median… 
2016
2016
A DUB-less step? Tighten up D-loop
DNA double-strand breaks (DSBs) can arise through exposure to exogenous DNA damaging agents such as ionizing radiation, as well… 
2015
2015
Targeting Deubiquitylating Enzyme USP1 in Multiple Myeloma
Introduction Proteasome inhibitor Bortezomib is effective therapy of relapsed/refractory and newly diagnosed multiple myeloma (MM… 
2015
2015
ReportRegulation of PCNA polyubiquitination in human cells
Background: The ubiquitin-based molecular switch dictating error free versus error prone repair has been conserved throughout… 
2015
2015
Conscious uncoupling between FANCI and FANCD2 in DNA repair
New model of the FA pathway activation. Non-phosphorylated, non-ubiquitinated FANCI plays a critical role in recruitment of the… 
2013
2013
Characterization Of Full-Length, Recombinant Amsh, USP9x, and USP1: Clinically-Relevant Deubiquitinases Involved In Hematological Malignancies
Attachment of polyubiquitin to substrate proteins generates important biological signaling cues that are inherent to the linkage… 
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