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UNC 0638

Known as: UNC-0638, UNC0638 
National Institutes of Health

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Broader (1)

Quinazolines

Papers overview

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2020
2020
The combination of G9a histone methyltransferase inhibitors with erythropoietin protects heart against damage from acute myocardial infarction.
BACKGROUND This study tested the hypothesis that combined histone methyltransferase G9a inhibitor (i.e., UNC0638) and… 
2017
2017
Histone Methyltransferases G9a and GLP; Identification and Validation of Novel Therapeutic Targets for Multiple Myeloma Treatment
Multiple myeloma (MM) is a virtually incurable clonal plasma cell malignancy which mainly resides in the bone marrow. Like in… 
2016
2016
Abstract 2657: Target specificity of epigenetic therapy in cancer
A major question facing the use of epigenetic therapies in cancer is specificity in modulating gene expression. In addition… 
2016
2016
Abstract LB-156: Delineating the pathological roles and molecular functions of histone methyltransferase G9a in hepatocellular carcinoma
Liver cancer, primarily hepatocellular carcinoma (HCC), is the third leading cause of cancer mortality worldwide. In HCC… 
2015
2015
Effect of epigenetic probes on IL-1B and polyIC treated normal human epithelial cells
Rationale: Asthma is an inflammatory disease of the airways. The airway epithelium is a major source of inflammatory mediators… 
2015
2015
Regulates Retention of G 9 a on Chromatin 1 A Role for Widely Interspaced Zinc Finger ( WIZ ) in Retention of the G 9 a Methyltransferase on Chromatin *
G9a and GLP lysine methyltransferases form a heterodimeric complex that is responsible for the majority of histone H3 lysine 9… 
2014
2014
Effects of the histone methyltransferase inhibitor UNC0638 on histone H3K9 dimethylation of cultured ovine somatic cells and development of resulting early cloned embryos.
Aberrant hypermethylation of histone H3 lysine 9 (H3K9) may be involved in the developmental failure of cloned embryos. UNC0638… 
2012
2012
hematopoietic stem cell lineage commitment G 9 a / GLP-dependent histone H 3 K 9 me 2 patterning during human Material Supplemental
  • 2012
  • Corpus ID: 207788997
Material Supplemental http://genesdev.cshlp.org/content/suppl/2012/10/24/gad.200329.112.DC1.html References http://genesdev.cshlp… 
2012
2012
Abstract 5006: High-throughput TR-FRET cellular assays for interrogating histone H3 methylation
Post-translational modifications such as phosphorylation, acetylation and methylation play important roles in regulating the… 
2011
2011
TR-FRET Cellular Assays for Interrogating Posttranslational Modifications of Histone H3
Posttranslational modifications such as phosphorylation, acetylation, and methylation play important roles in regulating the… 
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