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ULBP2 gene

Known as: UL16-BINDING PROTEIN 2, RAET1H, UL16 Binding Protein 2 Gene 
This gene plays a role in the function of natural killer cells.
National Institutes of Health

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Related topics

3 relations
NKG2D Ligand 2ULBP2 protein, human

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ULBP2 wt Allele

Papers overview

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Highly Cited
2016
Highly Cited
2016
NKG2D ligands mediate immunosurveillance of senescent cells
Cellular senescence is a stress response mechanism that limits tumorigenesis and tissue damage. Induction of cellular senescence… 
Highly Cited
2012
Highly Cited
2012
Tumor suppressive microRNAs miR-34a/c control cancer cell expression of ULBP2, a stress-induced ligand of the natural killer cell receptor NKG2D.
Malignant cells express ligands for the natural killer cell immunoreceptor NKG2D, which sensitizes to early recognition and… 
Highly Cited
2007
Highly Cited
2007
Reciprocal regulation of human natural killer cells and macrophages associated with distinct immune synapses.
Natural killer (NK) cells directly lyse tumor or viral-infected cells but also an important role for NK cell cytotoxicity in… 
Highly Cited
2007
Highly Cited
2007
Antigen-activated human T lymphocytes express cell-surface NKG2D ligands via an ATM/ATR-dependent mechanism and become susceptible to autologous NK- cell lysis.
Recent evidence indicates that natural killer (NK) cells can negatively regulate T-cell responses, but the mechanisms behind this… 
Highly Cited
2006
Highly Cited
2006
Proteolytic release of soluble UL16-binding protein 2 from tumor cells.
The MHC class I-related ligands of the immunoreceptor NKG2D are frequently expressed by tumor cells and stimulate tumor immunity… 
Highly Cited
2005
Highly Cited
2005
Role of NK Cell-Activating Receptors and Their Ligands in the Lysis of Mononuclear Phagocytes Infected with an Intracellular Bacterium1
We studied the role of NK cell-activating receptors and their ligands in the lysis of mononuclear phagocytes infected with the… 
Highly Cited
2005
Highly Cited
2005
Ligands for natural killer cell-activating receptors are expressed upon the maturation of normal myelomonocytic cells but at low levels in acute myeloid leukemias.
Natural killer (NK) cell-mediated cytolytic activity against tumors requires the engagement of activating NK receptors by the… 
Highly Cited
2003
Highly Cited
2003
Effects of Human Cytomegalovirus Infection on Ligands for the Activating NKG2D Receptor of NK Cells: Up-Regulation of UL16-Binding Protein (ULBP)1 and ULBP2 Is Counteracted by the Viral UL16 Protein1
Human CMV (HCMV) interferes with NK cell functions at various levels. The HCMV glycoprotein UL16 binds some of the ligands… 
Highly Cited
2003
Highly Cited
2003
Human Cytomegalovirus Glycoprotein UL16 Causes Intracellular Sequestration of NKG2D Ligands, Protecting Against Natural Killer Cell Cytotoxicity
The activating receptor, NKG2D, is expressed on a variety of immune effector cells and recognizes divergent families of major… 
Highly Cited
2003
Highly Cited
2003
Selective intracellular retention of virally induced NKG2D ligands by the human cytomegalovirus UL16 glycoprotein
Human cytomegalovirus (HCMV) has evolved a multitude of molecular mechanisms to evade the antiviral immune defense of the host… 
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