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UGT1A3 gene

Known as: UDP glucuronosyltransferase family 1 member A3, UGT1C, UDP-GLYCOSYLTRANSFERASE 1 FAMILY, POLYPEPTIDE A3 
National Institutes of Health

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Related topics

1 relation
UDP-glucuronosyltransferase, UGT1A3

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2015
2015
Glucuronidation of OTS167 in Humans Is Catalyzed by UDP-Glucuronosyltransferases UGT1A1, UGT1A3, UGT1A8, and UGT1A10
OTS167 is a potent maternal embryonic leucine zipper kinase inhibitor undergoing clinical testing as antineoplastic agent. We… 
2014
2014
Steviol glucuronidation and its potential interaction with UDP-glucuronosyltransferase 2B7 substrates.
Highly Cited
2012
Highly Cited
2012
Biotransformation of the Antiretroviral Drug Etravirine: Metabolite Identification, Reaction Phenotyping, and Characterization of Autoinduction of Cytochrome P450-Dependent Metabolism
Etravirine (ETR) is a second-generation non-nucleoside reverse transcriptase inhibitor prescribed for the treatment of HIV-1. By… 
2012
2012
Strong inhibition of deoxyschizandrin and schisantherin A toward UDP-glucuronosyltransferase (UGT) 1A3 indicating UGT inhibition-based herb–drug interaction.
Highly Cited
2007
Highly Cited
2007
Critical Roles of Residues 36 and 40 in the Phenol and Tertiary Amine Aglycone Substrate Selectivities of UDP-Glucuronosyltransferases 1A3 and 1A4
Despite high sequence identity, UGT1A3 and UGT1A4 differ in terms of substrate selectivity. UGT1A3 glucuronidates the planar… 
2007
2007
Hepatocyte nuclear factor 1 alpha and 4 alpha are factors involved in interindividual variability in the expression of UGT1A6 and UGT1A9 but not UGT1A1, UGT1A3 and UGT1A4 mRNA in human livers.
UDP-glucuronosyltransferases (UGTs) catalyze phase-II biotransformation reaction of a variety of substances. Among the UGT1A… 
Highly Cited
2007
Highly Cited
2007
Characterization of the UDP Glucuronosyltransferase Activity of Human Liver Microsomes Genotyped for the UGT1A1*28 Polymorphism
The UGT1A1*28 polymorphism is known to correlate with altered clearance of bilirubin (Gilbert syndrome) and drugs such as 7-ethyl… 
2007
2007
A pharmacogenomics study of the human estrogen glucuronosyltransferase UGT1A3
UGT1A3 is one of the most efficient at conjugating estrone, a precursor for biosynthesis of estradiol in peripheral tissues. We… 
Highly Cited
2006
Highly Cited
2006
The liver X‐receptor alpha controls hepatic expression of the human bile acid–glucuronidating UGT1A3 enzyme in human cells and transgenic mice
Glucuronidation, an important bile acid detoxification pathway, is catalyzed by enzymes belonging to the UDP… 
Highly Cited
2000
Highly Cited
2000
Distribution and inducibility by 3-methylcholanthrene of family 1 UDP-glucuronosyltransferases in the rat gastrointestinal tract.
UDP-Glucuronosyltransferases (UGT) catalyze the glucuronidation of a broad spectrum of endobiotic and xenobiotic substrates. The… 
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