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UGCG gene

Known as: CERAMIDE GLUCOSYLTRANSFERASE, UDP-Glucose Ceramide Glucosyltransferase Gene, GLUCOSYLCERAMIDE SYNTHASE 
This gene is involved in glucosylceramide synthesis.
National Institutes of Health

Papers overview

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2012
2012
Synthesis inhibition is the basis for the treatment of type 1 Gaucher disease by the glucosylceramide synthase (GCS) inhibitor… Expand
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Highly Cited
2009
Highly Cited
2009
BackgroundDrug resistance is the outcome of multiple-gene interactions in cancer cells under stress of anticancer agents. MDR1… Expand
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Highly Cited
2009
Highly Cited
2009
The number of recombination events per meiosis varies extensively among individuals. This recombination phenotype differs between… Expand
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Highly Cited
2005
Highly Cited
2005
Overexpression of glucosylceramide synthase (GCS), a pivotal enzyme in glycolipid biosynthesis, contributes to cancer cell… Expand
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Highly Cited
2004
Highly Cited
2004
Ceramide is a key mediator of apoptosis, and is involved in the cellular stress response. We examined the alterations in the… Expand
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Highly Cited
2001
Highly Cited
2001
Ceramide glycosylation, through glucosylceramide synthase (GCS), allows cellular escape from ceramide‐induced programmed cell… Expand
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Highly Cited
2000
Highly Cited
2000
Previous work from our laboratory demonstrated that increased competence to glycosylate ceramide conferred adriamycin resistance… Expand
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Highly Cited
1999
Highly Cited
1999
Multidrug-resistant cancer cells display elevated levels of glucosylceramide (Lavie, Y., Cao, H. T., Volner, A., Lucci, A., Han… Expand
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Highly Cited
1996
Highly Cited
1996
We have isolated a cDNA encoding human ceramide glucosyltransferase (glucosylceramide synthase, UDP-glucose:N-acylsphingosine D… Expand
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Highly Cited
1996
Highly Cited
1996
We present a method for solubilizing and purifying UDP-Glc:ceramide glucosyltransferase (EC 2.4.1.80; glucosylceramide synthase… Expand
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