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Chlorogenic acid exists widely in edible and medicinal plants and acts as an antioxidant. It is known to exert antitumor activity… Expand We investigated the signaling pathways associated with microtubule interaction and apoptosis in U937 cells in vitro and in the… Expand We have investigated the effects of sex steroids, estradiol (E2), and testosterone (T) on the synthesis of tumor necrosis factor… Expand 3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitors, or statins, have been reported to exert actions independent of their… Expand Cyclooxygenase-2 (COX-2), a rate-limiting enzyme for prostaglandins (PG), plays a key role in inflammation, tumorigenesis… Expand Soy protein-containing foods are a rich source of isoflavone phytoestrogens, such as genistein and daidzein. There is great… Expand Despite what is known about the early signaling events in tumor necrosis factor (TNF) α-induced apoptosis, characterization of… Expand Treatment of U937 human leukemic cells with the phorbol ester PMA, activates both mitogen-activated protein kinase (MAPK) and… Expand Intracellular pathways leading from membrane receptor engagement to apoptotic cell death are still poorly characterized. We… Expand Adhesion of monocytes to the arterial endothelium is an important early event in atherosclerosis. Several lines of evidence have… Expand