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U 54494A

Known as: U 54494, U-54494, U-54494A 
National Institutes of Health

Related topics

Related topics

2 relations

Broader (2)

AnticonvulsantsPyrrolidines

Papers overview

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1996
1996
Pharmacokinetics of the individual enantiomers of cis-3,4-dichloro-N-methyl-N-[2-(1-pyrrolidinyl)-cyclohexyl]-benzamide monohydrochloride (U-54494A) in the dog.
U-54494A, a racemic mixture of two enantiomers, is being developed in racemic form as an anticonvulsant drug candidate. A… 
Highly Cited
1995
Highly Cited
1995
The effects of anticonvulsant agents on 4-aminopyridine induced epileptiform activity in rat hippocampus in vitro
1993
1993
Anticonvulsant effects of U-54494A and U-50488H in genetically epilepsy-prone rats and DBA/2 mice: a possible involvement of glycine/NMDA receptor complex.
1993
1993
Inhibition of glutamate release: A potential mechanism of action for the anticonvulsant U-54494A in the guinea pig hippocampus
1993
1993
Two metabolites of anticonvulsant U-54494A: their anticonvulsant activity and interaction with sodium channel
1992
1992
Comparison of pyrrolidinyl and piperidinyl benzamides for their anticonvulsant activity and inhibitory action on sodium channel
1 A pair of benzamide analogues containing a pyrrolidinyl or piperidinyl group was examined for their anticonvulsant activity… 
1992
1992
Antagonism of kainic acid lesions in the mouse hippocampus by U-54494A and U-50488H.
1992
1992
U-54494A reduces 4-AP-induced afterdischarges of CA1 pyramidal cells in the hippocampal slice of the rat.
1991
1991
The kappa opioid-related anticonvulsants U-50488H and U-54494A attenuate N-methyl-D-aspartate induced brain injury in the neonatal rat
1991
1991
In vitro depressant effects of U-54494A, an anticonvulsant related to kappa opioids, in the hippocampus
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