Tropanes

Mutations in the gene encoding the dopamine-synthetic enzyme GTP cyclohydrolase-1 (GCH1) cause DOPA-responsive dystonia (DRD… Expand

Rhodium-catalyzed [4 + 3] cycloaddition between methyl 2-(siloxy)vinyldiazoacetate and pyrroles results in the enantioselective… Expand

Scopolamine is a pharmaceutically important tropane alkaloid extensively used as an anticholinergic agent. Here, we report the… Expand

Secondary metabolites, at least the major ones present in a plant, apparently function as defence (against herbivores, microbes… Expand

We investigated the microglial response to progressive dopamine neuron degeneration using in vivo positron emission tomography… Expand

Hairy root cultures of Brugmansia candida produce the tropane alkaloids scopolamine and hyoscyamine. In an attempt to increase… Expand

Rapid eye movement (REM) sleep behaviour disorder (RBD) is characterized by complex behaviour during REM sleep. The aetiology of… Expand

Hyoscyamine 6 beta-hydroxylase (H6H; EC 1.14.11.11) catalyzes the first reaction in the biosynthetic pathway from hyoscyamine to… Expand

Structure-activity relationships for cocaine and analog binding at the dopamine, norepinephrine and serotonin transporters were… Expand

We report here saturation analysis of [3H]cocaine binding in various mouse brain regions, and the necessary structure-activity… Expand