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How human neuroblastoma cells make morphine.
- C. Boettcher, M. Fellermeier, C. Boettcher, B. Dräger, M. Zenk
- Chemistry, BiologyProceedings of the National Academy of Sciences…
- 14 June 2005
The laboratory demonstrated that human neuroblastoma cells (SH-SY5Y) are capable of synthesizing morphine, the major active metabolite of opium poppy, which is further substantiated by extending the biochemical studies to the entire morphine pathway in this human cell line.
Alkaloids in plants and root cultures of Atropa belladonna overexpressing putrescine N-methyltransferase.
- G. Rothe, A. Hachiya, Yasuyuki Yamada, T. Hashimoto, B. Dräger
- BiologyJournal of experimental botany
- 1 September 2003
Putrescine N-methyltransferase (PMT) is the first alkaloid-specific enzyme for nicotine and tropane alkaloid formation. The pmt gene from Nicotiana tabacum was fused to the CaMV 35S promoter and…
Endogenous formation of morphine in human cells.
- C. Poeaknapo, Jürgen Schmidt, M. Brandsch, B. Dräger, M. Zenk
- Biology, ChemistryProceedings of the National Academy of Sciences…
- 28 September 2004
It is shown that all three alkaloids present in human neuroblastoma cells and human pancreas carcinoma cells are of biosynthetic origin and suggests that norlaudanosoline and (S)-reticuline are endogenous precursors of morphine.
Analysis of tropane and related alkaloids.
- B. Dräger
- ChemistryJournal of chromatography. A
- 29 November 2002
Overexpression of tropinone reductases alters alkaloid composition in Atropa belladonna root cultures.
- U. Richter, G. Rothe, A. Fabian, B. Rahfeld, B. Dräger
- Chemistry, BiologyJournal of experimental botany
- 1 February 2005
Transformation with cDNA of tropinone reductases successfully altered the ratio of tropine- derived alkaloids versus pseudotropine-derived alkaloid biosynthetic pathway in A. belladonna root cultures.
Medicinal Natural Products: A Biosynthetic Approach, 2nd Ed., Paul M. Dewick, Wiley (2001), £34.95; ISBN: 0-471-49641-3
- B. Dräger
- 1 April 2003
Glucosinolates in Moringa stenopetala.
Bio-guided fractionation of seed extracts from Moringa stenopetala resulted in a myrosinase hydrolysis product, 5,5-dimethyloxazolidine-2-thione. It is formed from the glucosinolate glucoconringiin,…
Putrescine N-methyltransferase--the start for alkaloids.
Calystegines in wild and cultivated Erythroxylum species.
Putrescine N-methyltransferases—a structure–function analysis
A protein model of PMT was based on the crystal structure of SPDS and suggests that overall protein folds are comparable, while the respective cosubstrates S-adenosylmethionine and decarboxylated S- adenosyl methionines appear to bind differentially to the active sites of both enzymes, and the substrate putrescine adopts a different position.