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Remarkable phenotype plasticity of epithelial cells underlies morphogenesis, epithelial repair and tumor invasiveness. Detailed… Expand Human embryonic stem cells (hESCs) self-renew indefinitely and give rise to derivatives of all three primary germ layers, yet… Expand Cancer patients can harbor significant numbers of CD8 and CD4 T cells with specificities to tumor antigens (Ags). Yet, in most… Expand The critical role of hyperglycemia in the genesis of diabetic nephropathy has been established by cell culture stud- ies… Expand Hero or villain? Trustworthy guardian of normal homeostasis or double agent? Over the past two decades, the perceived role of… Expand TGF-βs are potent inhibitors of epithelial cell proliferation. However, in established carcinomas, autocrine/paracrine TGF… Expand We are grateful to members of the Massague laboratory for insightful discussions. R. S. L. would like to thank S. H. Roan for all… Expand During early pregnancy, placentation occurs in a relatively hypoxic environment that is essential for appropriate embryonic… Expand Background: The most accurate predictor of disease recurrence in patients treated for head and neck squamous cell carcinoma is… Expand Abstract TGFβ signaling is initiated when the type I receptor phosphorylates the MAD-related protein, Smad2, on C-terminal serine… Expand