Triazenes

Known as: Triazene Compound, Triazene Compounds, Triazenes [Chemical/Ingredient] 
Any of a class of organic compounds having an amine directly attached to an azo group. Triazene compounds act as alkylating agents and cause… (More)
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1,3-di(4-sulfamoylphenyl)triazene1,3-diethyltriazene1,3-diphenyl-1-triazene1-4-(3-methyltriazeno)benzoic acid
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In Bloodagonistsantagonists & inhibitorsaspects of radiation effects
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Papers overview

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2012
2012
Ortho-trifluoromethylation of functionalized aromatic triazenes.
Fluorine containing organic agents play a crucial role in the search for new active pharmaceutical and agrochemical compounds… (More)
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Review
2007
Review
2007
Triazene compounds: mechanism of action and related DNA repair systems.
Triazene compounds of clinical interest (i.e. dacarbazine and temozolomide) are a group of alkylating agents with similar… (More)
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2007
2007
Novel role of triazenes in haematological malignancies: pilot study of Temozolomide, Lomeguatrib and IL-2 in the chemo-immunotherapy of acute leukaemia.
Previous studies indicated that dacarbazine and Temozolomide could be highly effective against refractory acute leukaemia. Their… (More)
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2005
2005
Mechanism of action of a novel "combi-triazene" engineered to possess a polar functional group on the alkylating moiety: evidence for enhancement of potency.
Previous studies showed that SMA41, a 3-methyltriazene termed "combi-molecules" possessing a dual epidermal growth factor… (More)
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2003
2003
The combi-targeting concept: chemical dissection of the dual targeting properties of a series of "combi-triazenes".
The combi-targeting concept postulates that a molecule termed a "combi-molecule" designed to interact with an oncoreceptor on its… (More)
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1999
1999
Treatment with temozolomide and poly(ADP-ribose) polymerase inhibitors induces early apoptosis and increases base excision repair gene transcripts in leukemic cells resistant to triazene compounds
Methylating triazenes have shown marked antileukemic effects, possibly through generation of a variety of DNA adducts. Cells… (More)
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Highly Cited
1998
Highly Cited
1998
Involvement of the mismatch repair system in temozolomide-induced apoptosis.
Postreplicative mismatch repair plays a major role in mediating the cytotoxicity of agents generating O6-methylguanine in DNA. We… (More)
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1995
1995
Chemosensitivity to triazene compounds and O6-alkylguanine-DNA alkyltransferase levels: studies with blasts of leukaemic patients.
BACKGROUND A clinical pilot study performed by our group showed that dacarbazine can induce a marked reduction of blast cells in… (More)
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1995
1995
Triazene compounds induce apoptosis in O6-alkylguanine-DNA alkyltransferase deficient leukemia cell lines.
Previous studies demonstrated that triazene compounds (TZC) possess antitumor, antimetastatic and immunosuppressive activity, and… (More)
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1974
1974
Chemotherapeutic, carcinogenic, and cell-regulatory effects of triazenes.
The following mouse strains were used: C57BL/6 x DBA2 F1 (hereafter called BD2F1), 6 to 10 weeks old (A. R. Schmidt Co., Madison… (More)
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