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Transcriptional Regulator ATRX

Known as: Znf-HX, X-Linked Nuclear Protein, XNP 
Transcriptional regulator ATRX (2492 aa, ~283 kDa) is encoded by the human ATRX gene. This protein plays a role in both chromatin remodeling and… 
National Institutes of Health

Related topics

Related topics

14 relations
ATP HydrolysisATRX geneATRX wt AlleleAdenosine Triphosphatases

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2018
Highly Cited
2018
Atrx inactivation drives disease-defining phenotypes in glioma cells of origin through global epigenomic remodeling
Mutational inactivation of the SWI/SNF chromatin regulator ATRX occurs frequently in gliomas, the most common primary brain… 
Highly Cited
2017
Highly Cited
2017
The chromatin remodelling factor ATRX suppresses R‐loops in transcribed telomeric repeats
ATRX is a chromatin remodelling factor found at a wide range of tandemly repeated sequences including telomeres (TTAGGG)n. ATRX… 
Highly Cited
2017
Highly Cited
2017
PML protein organizes heterochromatin domains where it regulates histone H3.3 deposition by ATRX/DAXX
Maintenance of chromatin homeostasis involves proper delivery of histone variants to the genome. The interplay between different… 
Highly Cited
2015
Highly Cited
2015
Atrx promotes heterochromatin formation at retrotransposons
More than 50% of mammalian genomes consist of retrotransposon sequences. Silencing of retrotransposons by heterochromatin is… 
Highly Cited
2015
Highly Cited
2015
The Daxx/Atrx Complex Protects Tandem Repetitive Elements during DNA Hypomethylation by Promoting H3K9 Trimethylation.
Highly Cited
2013
Highly Cited
2013
Drosophila Yemanuclein and HIRA Cooperate for De Novo Assembly of H3.3-Containing Nucleosomes in the Male Pronucleus
The differentiation of post-meiotic spermatids in animals is characterized by a unique reorganization of their nuclear… 
Highly Cited
2012
Highly Cited
2012
Compromised genomic integrity impedes muscle growth after Atrx inactivation.
ATR-X syndrome is a severe intellectual disability disorder caused by mutations in the ATRX gene. Many ancillary clinical… 
Highly Cited
2007
Highly Cited
2007
Structural consequences of disease-causing mutations in the ATRX-DNMT3-DNMT3L (ADD) domain of the chromatin-associated protein ATRX
The chromatin-associated protein ATRX was originally identified because mutations in the ATRX gene cause a severe form of… 
Highly Cited
2000
Highly Cited
2000
ATR-X mutations cause impaired nuclear location and altered DNA binding properties of the XNP/ATR-X protein
Mutations in the XNP/ATR-X gene, located in Xq13.3, are associated with several X linked mental retardation syndromes, the best… 
Review
1991
Review
1991
Non-specific X linked mental retardation.
Non-specific X linked mental retardation (MRX) is mental retardation in persons of normal physical appearance who have no… 
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