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Transcription Initiation Site

Known as: Transcription Start Sites, Site, Transcription Initiation, Sites, Transcription Initiation 
The first nucleotide of a transcribed DNA sequence where RNA polymerase (DNA-DIRECTED RNA POLYMERASE) begins synthesizing the RNA transcript.
National Institutes of Health

Related topics

Related topics

2 relations
aspects of radiation effectsphysiological aspects

Papers overview

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Highly Cited
2012
Highly Cited
2012
The long-range interaction landscape of gene promoters
The vast non-coding portion of the human genome is full of functional elements and disease-causing regulatory variants. The… Expand
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Highly Cited
2008
Highly Cited
2008
Dynamic Regulation of Nucleosome Positioning in the Human Genome
The positioning of nucleosomes with respect to DNA plays an important role in regulating transcription. However, nucleosome… Expand
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Highly Cited
2007
Highly Cited
2007
Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project
We report the generation and analysis of functional data from multiple, diverse experiments performed on a targeted 1% of the… Expand
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Highly Cited
2007
Highly Cited
2007
G-quadruplexes in promoters throughout the human genome
Certain G-rich DNA sequences readily form four-stranded structures called G-quadruplexes. These sequence motifs are located in… Expand
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Highly Cited
2006
Highly Cited
2006
Genome-wide analysis of mammalian promoter architecture and evolution
Mammalian promoters can be separated into two classes, conserved TATA box–enriched promoters, which initiate at a well-defined… Expand
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Highly Cited
2006
Highly Cited
2006
A PHD finger of NURF couples histone H3 lysine 4 trimethylation with chromatin remodelling
Lysine methylation of histones is recognized as an important component of an epigenetic indexing system demarcating… Expand
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Highly Cited
2005
Highly Cited
2005
Chromosome-Wide Mapping of Estrogen Receptor Binding Reveals Long-Range Regulation Requiring the Forkhead Protein FoxA1
Estrogen plays an essential physiologic role in reproduction and a pathologic one in breast cancer. The completion of the human… Expand
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Highly Cited
1997
Highly Cited
1997
The Organization, Promoter Analysis, and Expression of the Human PPARγ Gene*
PPARγ is a member of the PPAR subfamily of nuclear receptors. In this work, the structure of the human PPARγ cDNA and gene was… Expand
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Highly Cited
1987
Highly Cited
1987
CpG islands in vertebrate genomes.
Although vertebrate DNA is generally depleted in the dinucleotide CpG, it has recently been shown that some vertebrate genes… Expand
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Highly Cited
1983
Highly Cited
1983
The promoter-specific transcription factor Sp1 binds to upstream sequences in the SV40 early promoter
Fractionation of HeLa cell extracts reveals the presence of a promoter-specific transcription factor, Sp 1, which activates a… Expand
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