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Transcription Factor 7-Like 2

Known as: T Cell Transcription Factor 4, HMG Box Transcription Factor 4, Transcription Factor 7-Like 2 Protein 
A transcription factor that takes part in WNT signaling pathway. The activity of the protein is regulated via its interaction with BETA CATENIN… 
National Institutes of Health

Related topics

Related topics

20 relations
DNA-Binding ProteinsGenes, RegulatorIn BloodMelanogenesis Pathway

Papers overview

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Highly Cited
2014
Highly Cited
2014
Validation of Type 2 Diabetes Risk Variants Identified by Genome-Wide Association Studies in Han Chinese Population: A Replication Study and Meta-Analysis
Background Several genome-wide association studies (GWAS) involving European populations have successfully identified risk… 
Highly Cited
2013
Highly Cited
2013
Transferability and Fine Mapping of Type 2 Diabetes Loci in African Americans
Type 2 diabetes (T2D) disproportionally affects African Americans (AfA) but, to date, genetic variants identified from genome… 
2012
2012
Evaluation of genome-wide association study-identified type 2 diabetes loci in African Americans.
Type 2 diabetes (T2D) is up to twice as prevalent among African Americans as Caucasians. Recent genome-wide association studies… 
2010
2010
Disease-associated loci are significantly over-represented among genes bound by transcription factor 7-like 2 (TCF7L2) in vivo
Aims/hypothesisTranscription factor 7-like 2 (TCF7L2) has been strongly implicated in type 2 diabetes and cancer. Our goal was to… 
Highly Cited
2009
Highly Cited
2009
Examination of All Type 2 Diabetes GWAS Loci Reveals HHEX-IDE as a Locus Influencing Pediatric BMI
OBJECTIVE A number of studies have found that BMI in early life influences the risk of developing type 2 diabetes later in life… 
2006
2006
Positive Inter-Regulation between β-Catenin/T Cell Factor-4 Signaling and Endothelin-1 Signaling Potentiates Proliferation and Survival of Prostate Cancer Cells
Both malignant and normal prostate epithelial cells produce endothelin-1 (ET-1), a critical factor in prostate cancer (CaP… 
Highly Cited
2006
Highly Cited
2006
Predictive genetic testing for type 2 diabetes
May raise unrealistic expectations 
2004
2004
β-Catenin and Plakoglobin N- and C-tails Determine Ligand Specificity*
β-Catenin and plakoglobin are related proteins involved in the regulation of adherens junctions and desmosomes. Moreover, by… 
Highly Cited
2002
Highly Cited
2002
Metastasis-inducing dna regulates the expression of the osteopontin gene by binding the transcription factor Tcf-4.
Small 1,000-bp fragments of genomic DNA obtained from human malignant breast cancer cell lines when transfected into a benign rat… 
Highly Cited
1999
Highly Cited
1999
A Possible Role for the High Mobility Group Box Transcription Factor Tcf-4 in Vertebrate Gut Epithelial Cell Differentiation*
The Wingless (Wg)/Wnt signaling pathway activates High Mobility Group (HMG)-box transcription factors of the T-cell Factor (Tcf… 
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