FAQ

Transcription Factor 7-Like 2

Known as: T Cell Transcription Factor 4, HMG Box Transcription Factor 4, Transcription Factor 7-Like 2 Protein 
A transcription factor that takes part in WNT signaling pathway. The activity of the protein is regulated via its interaction with BETA CATENIN… (More)

Topic mentions per year

Topic mentions per year

1999-2017
05010019992017

Related topics

Related topics

23 relations
DNA-Binding ProteinsGenes, RegulatorHMG-BoxIn Blood
(More)

Related mentions per year

Related mentions per year

1936-2018
19401960198020002020
Transcription Factor 7-Like 2
Signal Transduction
physiological aspects
agonists
dna binding
Genes, Regulator

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2008
Highly Cited
2008
Clinical risk factors, DNA variants, and the development of type 2 diabetes.
BACKGROUND Type 2 diabetes mellitus is thought to develop from an interaction between environmental and genetic factors. We… (More)
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Highly Cited
2008
Highly Cited
2008
Transcription factor 7-like 2 regulates beta-cell survival and function in human pancreatic islets.
OBJECTIVE Type 2 diabetes is characterized by impaired insulin secretion in response to increased metabolic demand. This defect… (More)
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Highly Cited
2007
Highly Cited
2007
Impaired glucagon-like peptide-1-induced insulin secretion in carriers of transcription factor 7-like 2 (TCF7L2) gene polymorphisms
Polymorphisms in the transcription factor 7-like 2 (TCF7L2) gene are associated with type 2 diabetes and reduced insulin… (More)
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Highly Cited
2007
Highly Cited
2007
A variant in CDKAL1 influences insulin response and risk of type 2 diabetes
We conducted a genome-wide association study for type 2 diabetes (T2D) in Icelandic cases and controls, and we found that a… (More)
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Highly Cited
2007
Highly Cited
2007
A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants.
Identifying the genetic variants that increase the risk of type 2 diabetes (T2D) in humans has been a formidable challenge… (More)
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Highly Cited
2006
Highly Cited
2006
Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes
We have previously reported suggestive linkage of type 2 diabetes mellitus to chromosome 10q. We genotyped 228 microsatellite… (More)
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Highly Cited
2006
Highly Cited
2006
Association of transcription factor 7-like 2 (TCF7L2) variants with type 2 diabetes in a Finnish sample.
Transcription factor 7-like 2 (TCF7L2) is part of the Wnt signaling pathway. Genetic variants within TCF7L2 on chromosome 10q… (More)
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Highly Cited
2006
Highly Cited
2006
Polymorphisms in the transcription factor 7-like 2 (TCF7L2) gene are associated with type 2 diabetes in the Amish: replication and evidence for a role in both insulin secretion and insulin resistance…
Transcription factor 7-like 2 (TCF7L2) regulates genes involved in cell proliferation and differentiation. The TCF7L2 gene is… (More)
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2006
2006
Polymorphism in the transcription factor 7-like 2 (TCF7L2) gene is associated with reduced insulin secretion in nondiabetic women.
Recently, the transcription factor 7-like 2 (TCF7L2) gene on chromosome 10q25.2 has been linked with type 2 diabetes among… (More)
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Highly Cited
2006
Highly Cited
2006
Transcription factor TCF7L2 genetic study in the French population: expression in human beta-cells and adipose tissue and strong association with type 2 diabetes.
Recently, the transcription factor 7-like 2 (TCF7L2) gene has been associated with type 2 diabetes in subjects of European origin… (More)
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