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Transcription Factor 7-Like 2

Known as: T Cell Transcription Factor 4, HMG Box Transcription Factor 4, Transcription Factor 7-Like 2 Protein 
A transcription factor that takes part in WNT signaling pathway. The activity of the protein is regulated via its interaction with BETA CATENIN… Expand
National Institutes of Health

Related topics

Related topics

20 relations
DNA-Binding ProteinsGenes, RegulatorIn BloodMelanogenesis Pathway
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Papers overview

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Highly Cited
2012
Highly Cited
2012
Recurrent R-spondin fusions in colon cancer
Identifying and understanding changes in cancer genomes is essential for the development of targeted therapeutics. Here we… Expand
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Highly Cited
2010
Highly Cited
2010
Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge
Glucose levels 2 h after an oral glucose challenge are a clinical measure of glucose tolerance used in the diagnosis of type 2… Expand
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Highly Cited
2007
Highly Cited
2007
A Genome-Wide Association Study of Type 2 Diabetes in Finns Detects Multiple Susceptibility Variants
Identifying the genetic variants that increase the risk of type 2 diabetes (T2D) in humans has been a formidable challenge… Expand
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Highly Cited
2007
Highly Cited
2007
Impaired glucagon-like peptide-1-induced insulin secretion in carriers of transcription factor 7-like 2 (TCF7L2) gene polymorphisms
Aims/hypothesisPolymorphisms in the transcription factor 7-like 2 (TCF7L2) gene are associated with type 2 diabetes and reduced… Expand
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Highly Cited
2006
Highly Cited
2006
Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes
We have previously reported suggestive linkage of type 2 diabetes mellitus to chromosome 10q. We genotyped 228 microsatellite… Expand
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Highly Cited
2006
Highly Cited
2006
Polymorphisms in the Transcription Factor 7-Like 2 (TCF7L2) Gene Are Associated With Type 2 Diabetes in the Amish
Transcription factor 7-like 2 (TCF7L2) regulates genes involved in cell proliferation and differentiation. The TCF7L2 gene is… Expand
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Highly Cited
2006
Highly Cited
2006
Association of Transcription Factor 7-Like 2 (TCF7L2) Variants With Type 2 Diabetes in a Finnish Sample
Transcription factor 7-like 2 (TCF7L2) is part of the Wnt signaling pathway. Genetic variants within TCF7L2 on chromosome 10q… Expand
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Highly Cited
2006
Highly Cited
2006
Transcription Factor TCF7L2 Genetic Study in the French Population
Recently, the transcription factor 7-like 2 (TCF7L2) gene has been associated with type 2 diabetes in subjects of European origin… Expand
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Highly Cited
1998
Highly Cited
1998
Depletion of epithelial stem-cell compartments in the small intestine of mice lacking Tcf-4
Mutations of the genes encoding APC or ß-catenin in colon carcinoma induce the constitutive formation of nuclear ß-catenin/Tcf-4… Expand
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Highly Cited
1997
Highly Cited
1997
Constitutive Transcriptional Activation by a β-Catenin-Tcf Complex in APC−/− Colon Carcinoma
The adenomatous polyposis coli (APC) tumor suppressor protein binds to β-catenin, a protein recently shown to interact with Tcf… Expand
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