Tramadol

Known as: Cyclohexanol, 2-((dimethylamino)methyl)-1-(3-methoxyphenyl)-, cis-(+-)-, Tramadol [Chemical/Ingredient], (+)-trans-2-(Dimethylaminomethyl)-1-(m-methoxyphenyl)cyclohexanol 
A synthetic codeine analogue, Tramadol has central analgesic properties with effects similar to opioids, such as morphine and codeine, acting on… (More)
National Institutes of Health

Papers overview

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Review
2010
Review
2010
BACKGROUND AND OBJECTIVES This second European Federation of Neurological Societies Task Force aimed at updating the existing… (More)
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Highly Cited
2007
Highly Cited
2007
The influence of CYP2D6 genotype and CYP2D6 inhibitors on enantiomeric plasma levels of tramadol and O-desmethyltramadol as well… (More)
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Highly Cited
2003
Highly Cited
2003
PURPOSE To evaluate the efficacy and safety of a combination analgesic tablet (37.5 mg tramadol/325 mg acetaminophen) for the… (More)
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Highly Cited
2003
Highly Cited
2003
Genetic polymorphisms result in absent enzyme activity of CYP2D6 (poor metabolizers, PM) in about 10% of the Caucasian population… (More)
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Highly Cited
2003
Highly Cited
2003
The efficacy and safety of sustained-release tramadol compared to placebo in the treatment of post-herpetic neuralgia were… (More)
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Highly Cited
2000
Highly Cited
2000
UNLABELLED There has been growing interest in determining the possible immune consequences of opioid administration for the… (More)
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Highly Cited
1998
Highly Cited
1998
OBJECTIVE The objective of this study was to evaluate the efficacy and safety of tramadol in treating the pain of diabetic… (More)
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Highly Cited
1997
Highly Cited
1997
Objective: This study was designed to investigate whether the in vivo metabolism of tramadol was influenced by CYP2D6… (More)
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Highly Cited
1996
Highly Cited
1996
Tramadol inhibits norepinephrine reuptake, stimulates serotonin release, and acts with mu-opioid receptors by way of its… (More)
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Highly Cited
1992
Highly Cited
1992
Two independent clinical trials were conducted simultaneously. In one, tramadol and pethidine were compared in 30 patients by… (More)
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